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OALib Journal期刊
ISSN: 2333-9721
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含自由氨基酸侧链的温敏性微凝胶的制备及性能
DOI: 10.11777/j.issn1000-3304.2014.13419, PP. 963-969
Keywords: N-异丙基丙烯酰胺,微凝胶,自由氨基酸,温敏性,药物释放
Abstract:
采用无皂乳液聚合法使N-异丙基丙烯酰胺（NIPAM）、ε-丙烯酰基-L-赖氨酸（εACRLLY）和N，N-亚甲基双丙烯酰胺（BA）交联共聚，制备了含有自由氨基酸侧链的温敏性微凝胶.利用透射电子显微技术（TEM）、动态光散射技术（DLS）及浊度法对所制备的微凝胶的形态及相转变进行了表征.TEM结果表明，所得的微凝胶具有规则的球型形态，微凝胶的粒径随εACRLLY含量的增加而减小.DLS及浊度结果表明，微凝胶粒径呈单分散的窄分布，随着温度的升高，微凝胶粒径减小，有着明显的体积相转变温度（VPTT）；亲水单体εACRLLY的引入能够有效地调节共聚物微凝胶的VPTT，并且VPTT随εACRLLY含量的增加几乎呈线性上升.微凝胶在对盐酸阿霉素的药物释放研究表明，所制备的微凝胶在20℃，12h内释放了56%，37℃下释放了73%；37℃，pH=7.4下13h内释放73%，pH=4.5下基本释放完毕，该微凝胶表现出良好的药物缓释性能.
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