OALib Journal期刊
ISSN: 2333-9721
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壳交联pH响应型PLGA载药微球的制备与研究
DOI: 10.11777/j.issn1000-3304.2015.14234 , PP. 228-235
Keywords: PLGA微球 ,壳聚糖 ,香草醛 ,壳交联 ,pH环境响应型
Abstract:
首先采用一次乳化法制备出PLGA[聚(乳酸-羟基乙酸)]纳米微球,并通过静电吸附将阳离子聚合物壳聚糖修饰到PLGA微球表面,然后以香草醛为交联剂对壳聚糖进行化学交联,得到一种壳交联的pH响应型纳米微球(PCV),微球粒径为(277.60±38.01)nm,表面电位为(21.60±4.51)mV.微球稳定性评价结果显示微球在24h内粒径变化较小;流式细胞仪检测显示细胞对PCV微球的摄取量比未经修饰的PLGA微球的摄取量高;空白微球细胞毒性实验表明在空白微球浓度小于80μg/mL时细胞的存活率达93.24%.以多西他赛(DTX)为模型药物进行包载,该纳米微球DTX的载药率为7.48%,包封率为34.98%;体外药物释放实验显示,该微球在pH=5.0环境下孵育90h的药物积累释放率达58.66%,而在pH=7.4的环境下的药物积累释放率为50.63%;此外,载DTX微球毒性试验结果表明该载药微球对A549肺癌细胞有较强的杀伤作用,其IC50值可达0.0009μg/mL.
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