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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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全反式维甲酸合铜(II)配合物对DNA的切割和键合作用
, PP. 2153-2157
Keywords: 全反式维甲酸合铜(II),小牛胸腺DNA,切割,电化学
Abstract:
以荧光法、粘度法、凝胶电泳和电化学方法研究了全反式维甲酸合铜(Ⅱ)配合物与DNA的作用.结果表明,该配合物能在生理条件下有效切割质粒DNA,加入H2O2后发现该配合物的切割活性增强,说明该配合物对DNA的切割机理可能有两种氧化和水解.同时可使DNA的粘度增加,使EB-DNA体系的荧光强度降低.DNA的存在能导致该配合物氧化还原峰电流降低.据此推断,该配合物主要以嵌入方式与DNA作用.
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