OALib Journal期刊
高对映选择性的有机催化的硝基烷烃对N-Boc靛红亚胺的不对称aza-Henry反应
DOI: 10.6023/A14040335
Keywords: 有机催化 ,aza-Henry反应 ,靛红亚胺 ,硝基烷烃 ,胺基季碳氧化吲哚
Abstract:
研究实现了高对映选择性的硝基烷烃对N-Boc靛红亚胺1的不对称aza-Henry反应，来构建胺基季碳氧化吲哚.发现在金鸡纳碱衍生的叔胺-酚羟基双功能催化剂C5的作用下，10种不同取代的N-Boc靛红亚胺与硝基甲烷的反应均能顺利进行，以66%～91%的对映选择性得到目标产物，产物的绝对构型通过X-ray单晶衍射加以确定.硝基乙烷和硝基丙烷也能高对映选择性地参与反应，但非对映选择性不佳.
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