全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

基于MR图像的阿尔茨海默病和轻度认知障碍患者海马三维纹理分析

Keywords: 阿尔茨海默病,轻度认知障碍,三维纹理分析,磁共振图像

Full-Text   Cite this paper   Add to My Lib

Abstract:

阿尔茨海默病(Alzheimerdisease,AD)是老年痴呆症中最常见的类型,有研究表明,轻度认知障碍(mildcognitiveimpairment,MCI)可能是AD的前驱阶段.研究样本包括21例早期AD患者(AD组)、22例MCI患者(MCI组)及20例健康对照者(normalcontrol,NC)的磁共振(magneticresonance,MR)脑图像,采用灰度共生矩阵和游程长矩阵方法对图像中海马结构进行三维纹理分析,比较纹理特征——能量、熵、游程长不均匀度因子和灰度不均匀度因子在3组之间的差异,并分析这些纹理参数与临床广泛应用的简易智能状态检查量表评分之间的相关性,同时利用支持向量机方法对样本进行分类识别.研究结果显示,以上纹理参数在3组之间存在显著差异,且纹理参数与临床简易智能状态检查量表评分具有相关性,对AD组与NC组的分类正确率可达85.37%(敏感性和特异性分别为90.48%、80%).表明三维纹理分析反映出了早期AD及MCI患者海马结构的病理变化,有助于AD的早期诊断.

References

[1]  江桂莲,李昕,李帅锋,等.阿尔茨海默症患者MR图像胼胝体和扣带回部位纹理分析[J].北京生物医学工程,2010,29(2):130-135.JIANG Gui-lian,LI Xin,LI Shuai-feng,et al.Textureanalysis of corpus callosum and cingulate on magneticresonance image in patients with alzheimer's disease[J].Beijing Biomedical Engineering,2010,29(2):130-135.(in Chinese)
[2]  周晓霞,张景,刘卓,等.基于MR图像女性阿尔茨海默症海马纹理特征研究[J].北京生物医学工程,2010,29(3):230-234.ZHOU Xiao-xia,ZHANG Jing,LIU Zhuo,et al.Texturecharacteristic analysis of hippocampus based on MRimages of female patients with alzheimer's disease[J].Beijing Biomedical Engineering,2010,29(3):230-234.(in Chinese)
[3]  FRODL T,MEISENZAHL E M,ZETZSCHE T,et al.Hippocampal changes in patients with a first episode ofmajor depression[J].Am J Psychiatry,2002,159(7):1112-1118.
[4]  MAHMOUD-GHONEIMA D,TOUSSAINTB G,CONSTANS J M,et al.Three dimensional texture analysis in MRI:a preliminary evaluation in gliomas[J].Magnetic Resonance Imaging,2003,21:983-987.
[5]  罗述谦,周果宏.医学图像处理与分析[M].北京:科学出版社,2003:33-37.
[6]  GRACE J,NADLER J D,WHITE D A,et al.Folstein vs modified mini-mental state examination in geriatric stroke:stability,validity,and screening utility[J].Arch Neurol,1995,52:477-484.
[7]  GEORGIADIS P,CAVOURAS D,KALATZIS I,et al.Enhancing the discrimination accuracy between metastases,gliomas and meningiomas on brain MRI by volumetric textural features and ensemble pattern recognition methods[J].Magnetic Resonance Imaging,2009,27:120-130.
[8]  YUA O,PARIZEL N,PAIN L,et al.Texture analysis of brain MRI evidences the amygdala activation by nociceptive stimuli under deep anesthesia in the propofol-formalin rat model[J].Magnetic Resonance Imaging,2007,25:144-146.
[9]  彭丹涛,许贤豪,刘江红,等.简易智能精神状态检查量表检测老年期痴呆患者的应用探讨[J].中国神经免疫学和神经病学杂志,2005,12(4):187-190.PENG Dan-tao,XU Xian-hao,LIU Jiang-hong,et al.Discussion on appl ication of MMSE for senile dementiapatients[J].Chinese Journal of Neuroimmunology andNeurology,2005,12(4):187-190.(in Chinese)
[10]  FRISONI G B,GANZOLA R,CANU E,et al.Mappinglocal hippocampal changes in Alzheimer's disease andnormal ageing with MRI at 3 Tesla[J].Brain,2008,131:3266-3276.
[11]  MUSKULUS M,SCHEENSTRA A E H,BRAAKMAN N,et al.Prospects for early detection of Alzheimer's diseasefrom serial MR images in transgenic mice[J].CurrentAlzheimer Research,2009,6(6):503-518.
[12]  Alzheimer's disease international[R].World AlzheimerReport,2009.
[13]  ZHANG Z X,ZAHNER G E,ROMAN G C,et al.Dementia subtypes in China:prevalence in Beijing,Xi'an,Shanghai,and Chengdu[J].Arch Neurol,2005,62(3):447-453.
[14]  BROOKMEYER R,GRAY S,KAWAS C,et al.Projection of Alzheimer's disease in the united states andthe public health impact of delaying disease onset[J].American Journal of Public Health,1998,88(9):1337-1342.
[15]  CARRILLO M C,BLACKWELL A,HAMPEL H,et al.Early risk assessment for Alzheimer's disease[J].Alzheimer's&Dementia,2009,5(2):182-196.
[16]  王鲁宁.老年人轻度认知功能障碍的研究进展[J].中华保健医学杂志,2009,11(4):251-253.WANG Lu-ning.Research progress of the aged with MCI[J].Chinese Journal of Health Care and Medicine,2009,11(4):251-253.(in Chinese)
[17]  SCHER A I,XU Y,KORF E S C,et al.Hippocampalshape analysis in Alzheimer's disease:a population-basedstudy[J].NeuroImage,2007,36:8-18.
[18]  HARRISON L,DASTIDAR P,ESKOLA H,et al.Textureanalysis on MRI images of non-Hodgkin lymphoma[J].Computers in Biology and Medicine,2008,38:519-524.
[19]  JAFARI-KHOUZANI K,ELISEVICH K,PATEL S,et al.FLAIR signal and texture analysis for mesialtemporal lobe epilepsy[J].Neuroimage Lateralizing,2010,49(2):1559-1571.
[20]  TAKAHASHI T,MURATA T,NARITA K,et al.Multifractal analysis of deep white matter microstructuralchanges on MRI in relation to early-stage atherosclerosis[J].Neuro Image,2006,32:1158-1166.
[21]  章毓晋.图像工程(中册):图像分析[M].2版.北京:清华大学出版社,2005:282-288.
[22]  XU DH,KURANI A,FURST J,et al.Run-lengthencoding for volumetric texture[C]∥Proceedings of the4th IASTED International Conference on Visualization,Imaging,and Image Processing,2004:6-8.
[23]  郝晶,李坤成,李可,等.基于体素的MRI形态分析诊断Alzheimer病的价值[J].中华放射学杂志,2005,39(10):1028-1033.HAO Jing,LI Kun-cheng,LI Ke,et al.A voxel-based MRI morphometric study of Alzheimer's disease[J].Chinese Journal of Radiology,2005,39(10):1028-1033.(in Chinese)
[24]  CHETELAT G,FOUQUET M,KALPOUZOS G,et al.Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry[J].Neuropsychologia,2008,46:1721-1731.
[25]  KANTARCI K,JACK CR,XU YC,et al.Mild cognitive impairment and Alzheimer disease:regional diffusivity of water[J].Radiology,2001,219:101-107.
[26]  ZHANG Bing,LI Ming,SUN Zong-zheng,et al.Evaluation of functional MRI markers in mild cognitive impairment[J].Journal of Clinical Neuroscience,2009,16:635-641.
[27]  MEGURO K,LEMESTRIC C,LANDEAU B,et al.Relations between hypometabolism in the posterior association neocortex and hippocampal atrophy in Alzheimer's disease:a PET/MRI correlative study[J].Neurol Neurosurg Psychiatry,2001,71:315-321.
[28]  FRISONI G B,TESTA C,ZORZAN A,et al.Detection of grey matter loss in mild Alzheimer's disease with voxelbased morphometry[J].Neurol Neurosurg Psychiatry,2002,73:657-667.
[29]  昂秋青,江开达,张明园,等.阿尔茨海默病脑磁共振研究[J].上海精神医学,2000,12(4):190-193.ANG Qiu-qing,JIANG Kai-da,ZHANG Ming-yuan,et al.A MRI study of Alzheimer's disease[J].Shanghai Archives of Psychiatry,2000,12(4):190-193.(in Chinese)
[30]  EL-BAZ A,CASANOVA M F,GIMEL'FARB G,et al.Autism diagnostics by3D texture analysis of cerebral white matter gyrifications[C]∥International Conference on Medical Image Computing and Computer-Assisted Intervention(MICCAI2007),2007,10(Pt2):882-890.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133