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阻断HIV-1进入细胞的抑制剂研究

Keywords: 附着抑制剂,融合抑制剂,进入抑制剂,人类免疫缺陷病毒HIV-1

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Abstract:

为了解决HlV-1病毒耐药的难题,研究阻断病毒进入细胞的抑制剂是一个重要途径,通过对近年来国内外学者在阻断HIV-1病毒进入宿主细胞的抑制剂方面所发表的文献进行分析,概述了阻断HIV-1病毒进入宿主细胞的抑制剂的研究进展.阻断病毒进入细胞的抑制剂具有强大的抗逆转录病毒作用,它的优势在于可以对抗目前所有的HIV-1耐药毒株,它分为阻断病毒与细胞吸附的抑制剂、阻断病毒进入的抑制剂及阻断病毒与细胞融合的抑制剂.提出了研究抑制剂时可考虑的几个不同靶点.

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