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DNA序列与剪接位点的关联性分析

Keywords: 基因,剪接,供体位点,神经网络

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Abstract:

为了进一步研究剪接位点识别算法,提高预测准确率,利用人工神经网络识别方法,选取不同的剪接序列样本进行试验,分析了供体位点邻近序列对于基因剪接的影响,对DNA序列与剪接的关联性进行了深入的研究.研究发现,剪接位点区别于伪剪接位点的特征信息同时存在于剪接位点邻近两侧大约50个碱基范围内的外显子和内含子中,且内含子相对于外显子包含了更多的特征信息.

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