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有依从性观测的临床试验模型的参数估计

Keywords: 拟似然,依从性,异方差模型,渐进正态性

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Abstract:

为了研究依从性对药物效果的影响,对一种结构线性模型,结合最小二乘和拟似然的思想,提出了一种新的参数估计方法,并在一般的条件下,证明了参数估计的相合性和渐近正态性.计算机模拟表明,这种方法不仅计算简单,有好的大样本性质,而且对于中小样本也有小的均方误差.

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