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边介数聚类算法在肿瘤基因表达谱中的应用

Keywords: 边介数,聚类算法,模块度,结肠癌,基因表达谱

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Abstract:

基于肿瘤基因表达谱研究了肿瘤相关基因及其功能模块的聚类算法,同时利用模块度评价了算法的有效性.通过与层次聚类算法的比较,证明边介数聚类算法在肿瘤基因功能模块聚类方面具有一定的有效性和实用性.以人结肠癌基因表达谱为研究对象,应用边介数聚类算法将158个从2万多个原始数据中提取的特征基因聚成7种功能类.通过GO数据库检索进一步证明这7类基因具有明确的生物学功能和意义.

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