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心血管系统在心衰阶段的生理模拟

Keywords: 心力衰竭,心血管系统,集中参数模型

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Abstract:

心衰患者的心血管系统发生了结构或机理上的变化,为了研究心衰阶段心血管系统血流动力学参数之间的关系,建立了一个由左心室、左心房、右心室、右心房、体循环系统、肺循环系统组成的心血管系统集中参数模型.模型中用右房压表征心脏的回心血量,即前负荷;用外周阻力、血液惯性和血管顺应性等表征心脏后负荷;通过时变弹性函数反映心肌收缩力.本文建立心血管系统三元件集中参数模型,并提出了基于临床数据的心肌收缩力的计算方法.运用此方法计算心衰患者心肌收缩力,并带入模型进行仿真.仿真结果表明,此模型可模拟心衰血流动力学变化,为心衰治疗提供理论支持.

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