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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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ZnHA/TiO2复合涂层的制备及生物相容性
DOI: 10.3724/SP.J.1037.2010.00448, PP. 429-434
Keywords: Zn,Ti,TiO2,羟基磷灰石,成骨细胞,生物相容性
Abstract:
为改善羟基磷灰石(HA)涂层与Ti基体的结合性能及成骨性能,在纯Ti表面先通过微弧氧化方法形成多孔TiO2,然后通过溶胶-凝胶法在其上形成ZnHA生物涂层.利用SEM和XRD观察和分析样品的表面形貌和物相组成,采用火焰原子吸收分光光度法测量Zn2+的释放浓度.将MG-63细胞直接接种于样品表面,评价成骨细胞在样品表面的黏附和增殖.噻唑蓝(MTT)比色分析结果表明,细胞在ZnHA/TiO2-2和ZnHA/TiO2-3涂层的样品表面增殖率比对照组(HA)显著增加,倒置荧光显微镜下可观察到细胞在改性样品表面黏附和伸展良好.由此表明,带有ZnHA/TiO2复合涂层的Ti种植体应具有更好的机械结合性能和生物相容性.
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