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OALib Journal期刊
ISSN: 2333-9721
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具有抗炎、抗过敏活性磷脂酶抑制剂的研究进展
Keywords: 磷脂酶A？2,磷脂酶C,磷脂酶D,磷脂酶抑制剂
Abstract:
磷脂酶参与细胞跨膜信息传递,磷脂酶A2还是机体炎症、过敏介质产生的关键酶。因此,磷脂酶抑制剂的合成研究对研究细胞表达某种功能的信息传递机制及与磷脂酶A2激活相关的疾病治疗机制和药物研究具有重要意义。本文主要综述了近期有关磷脂酶A2抑制剂的合成、结构、抑效性能、构效关系及应用前景等,对磷脂酶C和磷脂酶D的抑制剂作了简要介绍。
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