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OALib Journal期刊
ISSN: 2333-9721
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基质金属蛋白酶抑制剂设计的研究进展*
Keywords: 基质金属蛋白酶,抑制剂,基于底物的药物设计,基于结构的药物设计,组合化学,SAR-by-NMR
Abstract:
基质金属蛋白酶(MMP)是一类含锌的水解酶,过量的MMP会加速细胞外基质的降解并导致一系列的疾病,例如癌症、关节炎和多发性硬化症等。因此MMP抑制剂的研究已成为药物设计研究领域中的一个热门课题。近年来,科学家们发展了三种分子设计的方法,包括基于底物的药物设计、基于结构的药物设计和组合化学技术。本文介绍了这些方法的原理及其在MMP抑制剂设计中的应用和进展。
| [1] | [ 2 ] 翟中和(Zhai Z H) 等. 细胞生物学(Cytobiology). 北京: 高等教育出版社, 1995. 83—92
|
| [2] | [ 3 ] Cawston T E, Galloway W A , Merce E, Murphy G, Reynolds J J. Biochem. J. , 1981, 195: 159—165
|
| [3] | [ 7 ] Shapiro S D, Kobayashi D K, Ley T J. J. Biol. Chem. , 1993,268: 23824—23829
|
| [4] | [ 9 ] Will H, Hinzmann B. Eur. J. Biochem. , 1995, 231: 602- 608
|
| [5] | [ 10 ] 赵云阁(Zhao Y G) , 欧尔比特·安尼瓦尔(Orbit Anwar) , 祝诚(Zhu C) , 生物化学和生物物理进展(Progress in Biochemistry and Biophysics) , 1999, 26: 223—228
|
| [6] | [ 12 ] Borkakoti N. P rog. Biophys. Mol. Biol. , 1998, 70: 73—94
|
| [7] | [ 14 ] Springman E B, Angleton E L , Birkedal-Hansen H, VanWart H E. Proc. Natl. Acad. Sci. U SA , 1990, 87: 364—368
|
| [8] | [ 16 ] Johnson W H, Roberts N A , Borkakoti N. J. Enz. Inhib. ,1987, 2: 1
|
| [9] | [ 18 ] Grams F, Reinemer P, Powers J C, Kleine T, Pieper M ,Tschesche H, Huber R, Bode W. Eur. J. Biochem. , 1995,228: 830—841
|
| [10] | [ 19 ] Castelhano A L , Billedeau R, Dewdney N , et al. Bioorg.Med. Chem. Lett. , 1995, 5: 1415
|
| [11] | [ 21 ] Maskos K, Fernandez-Catalan C, Huber R, et al. Proc. Natl.Acad. Sci. USA , 1998, 95: 3408—3412
|
| [12] | [ 23 ] Crimmin M J , Beckett P R, Davis M H. PCT Patent Application, WO 9421625, 1994 ( Chem. A bstr. , 1995, 122:188173)
|
| [13] | [ 26 ] 麻锦彪(Ma J B) , 吴厚铭(Wu H M ). 化学进展( Progress in Chemistry) , 1999, 11: 265—274
|
| [14] | [ 28 ] Ferry G, Boutin J A , Hennig P, et al. Eur. J. Pharmacol. ,1998, 351: 225—233
|
| [15] | [ 38 ] Hajduk P J , Sheppard G, Netteshein D G, et al. J. Am.Chem. Soc. , 1997, 119: 5818- 5827
|
| [16] | [ 1 ] Liotta L A , Rao C N , Wewer U M. Ann. Rev. Biochem. ,1986, 55: 1037—1057
|
| [17] | [ 4 ] Greene J , Wang M , Liu Y E, Raymond L A , Rosen C, Shi Y E. J. Biol. Chem. , 1996, 271: 30375—30380
|
| [18] | [ 5 ] Massova I, Kotra L P, Fridman R, Mobashery S. Faseb. J. ,1998, 12: 1075—1095
|
| [19] | [ 6 ] Woessner J F. Faseb. J. , 1991, 5: 2145—2154
|
| [20] | [ 8 ] Takino T, Sato H, Shinagawa A , Seiki M. J. Biol. Chem. ,1995, 270: 23013—23020
|
| [21] | [ 11 ] Whittaker M , Floyd C D, Brown P, Gearing A J H. Chem.Rev. , 1999, 99: 2735—2776
|
| [22] | [ 13 ] VanWart H E, Birkedal-Hansen H, Proc. Natl. Acad. Sci.USA , 1990, 87: 5578—5582
|
| [23] | [ 15 ] Lovejoy B, Hassell A M , L uther M A , Weigl D, Jordan S R.Biochemistry, 1994, 33: 8207—8217
|
| [24] | [ 17 ] Babine R E, Bender S L. Chem. Rev. , 1997, 97: 1359
|
| [25] | [ 20 ] Miller A , Askew M , Beckett R P, et al. Bioorg. Med.Chem. Lett. , 1997, 7: 193
|
| [26] | [ 22 ] Beckett R P, Davidson A H, Drummond A H, et al. Drug Discovery Today, 1996, 1: 16
|
| [27] | [ 24 ] Gallop M A , Barrett R W , Dower W J , et al. J. Med.Chem. , 1994, 37: 1233—1251
|
| [28] | [ 25 ] Gordon E M , Barrett R W , Dower W J , et al. J. Med.Chem. , 1994, 37: 1385—1401
|
| [29] | [ 27 ] Esser C K, Kelvin N J , Yates N A , Chapman K T. Bioorg.Med. Chem. Lett. , 1997, 7: 2639
|
| [30] | [ 29 ] Rockwell A , Melden M , Copeland R A , et al. J. Am. Chem.Soc. , 1996, 118: 10337
|
| [31] | [ 30 ] Foley M A , Hassman A S, Drewry D H, et al. Bioorg. Med.Chem. Lett. , 1996, 6: 1905
|
| [32] | [ 31 ] Szardenings A K, Harris D, Lam S, et al. J. Med. Chem. ,1998, 41: 2194—2200
|
| [33] | [ 32 ] Szardenings A K, A ntonenko V , Campbell D A , et al. J.Med. Chem. , 1999, 42: 1348—1357
|
| [34] | [ 33 ] Campbell D A , Bermak J C, Burkoth T S, Patel D V. J. Am.Chem. Soc. , 1995, 117: 5381
|
| [35] | [ 34 ] Ni Z J , Maclean D, Holmes C P, et al. J. Med. Chem. ,1996, 39: 1601- 1608
|
| [36] | [ 35 ] Jeng A Y, Chou M , Parker D T. Bioorg. Med. Chem. Lett. ,1998, 8: 897
|
| [37] | [ 36 ] Smith P W , Lai J Y Q , Whittington A R, et al. Bioorg. Med.Chem. Lett. , 1994, 4: 2821
|
| [38] | [ 37 ] Hajduk P J , Meadow s R, Fesik S W. Science, 1997, 278:497- 499
|
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