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化学进展  2012 

刺激响应型功能聚合物的合成及应用

, PP. 2198-2211

Keywords: 功能性聚合物,刺激-响应,双亲性,可控/活性自由基聚合,药物载体

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Abstract:

刺激响应型聚合物是一类功能性聚合物,它在药物控制释放、基因载体、纳米粒子以及纳米反应器等众多领域具有广阔的应用前景,因此引起了越来越多科学工作者的关注。刺激响应型聚合物多为双亲性聚合物,可通过自组装的方式得到形态各异的聚集体,如胶束、囊泡等。在受到某些外界环境刺激时,它们会产生特异性响应,尤其是功能性聚合物嵌段会发生相应的变化,从而引起整个聚合物结构的相转变和体积相转变。根据环境刺激种类的不同,刺激响应型聚合物可以分成不同类型,本文主要介绍了pH、温度、光、分子、电化学和手性等响应型聚合物,并概括了它们的结构特点以及不同的合成方法,简单说明了它们具有刺激响应功能的作用机理,阐述了结构与性能的联系。另外,还介绍了它们的潜在应用,并对此类聚合物的发展前景作了展望。

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