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化学进展  2012 

SERS技术在疾病诊断和生物分析中的应用

, PP. 2391-2402

Keywords: 表面增强拉曼散射(SERS),生物大分子,病原微生物,细胞,活体

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Abstract:

表面增强拉曼散射(surface-enhancedRamanscattering,SERS)技术以其独特的谱带窄、灵敏度高、抗光漂白、原位和无损等优势,在疾病诊断和生物分析领域得到了越来越广泛的应用。本文介绍了近几年来应用于生物大分子、病原微生物、细胞和活体检测分析中的最新SERS技术,并分别从标记与非标记的角度对其进行了阐述,总结了SERS标记检测生物大分子的基本识别模式,简述了检测低浓度病原微生物的SERS技术,着重评述了SERS检测技术在细胞和活体研究中的应用,并对基于SERS的疾病诊断和生物分析技术的发展趋势进行了初步展望。

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