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OALib Journal期刊
ISSN: 2333-9721
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新型亲核NO共体Diazeniumdiolate及其靶向性控释材料*
, PP. 1101-1109
Keywords: 一氧化氮,NO,供体,diazeniumdiolates,亲核试剂,靶向性释放
Abstract:
新型亲核NO供体diazeniumdiolate独特的化学结构和性质,使其成为目前NO供体研究的一个热点。要使其成为更有效的药物,它的靶向性和控释性能是当前研究的重点,减小亲核试剂(多胺)的细胞毒性和亚硝胺的生成是研究的难点。本文对增强靶向性释放所采取的三个措施(聚合物控释、特定酶代谢释放和光降解释放)的近十几年国外的研究情况进行了综述。
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