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化学进展  2011 

超临界流体输运技术在缓/控释药物制备中的应用

, PP. 1611-1617

Keywords: 超临界流体,输运技术,浸渍与沉积,缓/控释药物,释放

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Abstract:

缓/控释药物制剂作为一种新药剂是药学研究的热点。本文对近年来超临界流体技术在缓/控释药物系统制备中的研究成果进行了回顾和总结,重点对以超临界流体为溶剂、无机介孔材料为载体制备缓/控释药物系统的方法进行了阐述和评价,内容包括技术原理、工艺流程、主要影响因素、药效试验、与传统方法比较等。分析了各种工艺流程的优缺点,并指出超临界流体输运技术在缓/控释药物系统制备中所具有的优势。在此基础上,提出药物溶于超临界二氧化碳后所形成的超临界二氧化碳溶液在多孔材料纳米级孔道内的渗透、扩散以及表面物理化学吸附机理、在特定环境氛围下的控制释放机制、药物超临界溶液热力学模型以及制备过程动力学研究等是应该重点关注的理论问题。

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