|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
Aβ蛋白分泌酶抑制剂研究进展
Keywords: Aβ蛋白,β分泌酶,抑制剂,AD
Abstract:
Aβ蛋白是淀粉样前体蛋白的代谢产物,它在脑组织中含量的异常增加可能是诱发AD的主要因素.应用分泌酶抑制剂可有效减少Aβ的生成,缓解患者症状.本文综述了其中的β分泌酶抑制剂的研究进展.
| [1] | [ 1 ] WHO. The World Health Report 2001. World Health Organization , France , 2001 : 19 —41
|
| [2] | [ 3 ] Arendt T. Neurosience , 2001 , 102 : 723 —765
|
| [3] | [ 4 ] Morris J C. J Clin. Invest . , 1999 , 104 : 1171 —1173
|
| [4] | [ 5 ] Racchi M, Govoni S. Trends Pharmacol . Sci . , 1999 , 20 : 418 —423
|
| [5] | [ 9 ] Selkoe D. Nature , 1999 , 399A: 23 —31
|
| [6] | Arun K, Lin H , Jordan T. Curr. Med. Chem. , 2002 , 9 :1135 —1144
|
| [7] | Selkoe D J . Science , 1997 , 275 : 630 —631
|
| [8] | Hardy J . Trends Neurosci . , 1997 , 20 : 154 —159
|
| [9] | Selkoe D J . Annu. Rev. Cell . Dev. Biol . , 1994 , 10 : 373 —403
|
| [10] | Hussain I , Powell D , Howlett D , et al . Mol . Cell Neurosci . ,1999 , 14 : 419 —427
|
| [11] | Wolfe M S , Xia W, Moore C L , et al . Biochemistry , 1999 , 38 :4720 —4727
|
| [12] | Bennett B D , Babu-khan S , Loeloff R , et al . J . Biol . Chem. ,2000 , 275 : 20647 —20651
|
| [13] | Yan R , Munzner J B , Shuck M E , et al . J . Bib. Chem. , 2001 ,276 : 34019 —34027
|
| [14] | Ghosh A K, Bilcer G, Harwood C , et al . J . Med. Chem. ,2001 , 44 : 2865 —2868
|
| [15] | Turner R T, Koelsch G, Hong L , Castenheira P , et al . Biochemistry , 2001 , 40 : 10001 —10006
|
| [16] | Marciniszyn J , Hartsuck J A , Tang J . J . Biol . Chem. , 1976 ,251 : 7088 —7094
|
| [17] | Steinhilb M L , Turner R S , Gaut J R. J . Biol . Chem. , 2001 ,276 : 4476 —4484
|
| [18] | Hong L , Koelsch G, Lin X, et al . Science , 2000 , 290 : 150 —154
|
| [19] | John V , Tang J , FangL , et al . PCT Int-Appl . , 2000 , WO 0 077030Al .
|
| [20] | Hom R , Mamo S , Tang J , et al . PCT Int-Appl . , 2001 , WO 0170 672A2
|
| [21] | Jay S T, David L D , John P A , et al . J . Med. Chem. , 2002 ,45 : 259 —262
|
| [22] | Miyamato M, Matsui J , Fukumoto H , et al . PCT Int-Appl . ,2001 , WO 0 187 293 A1
|
| [23] | [ 2 ] Enz A , Amstutz R , Boddoke H , et al . Prog. Brain Res. , 1993 ,98 : 431 —438
|
| [24] | [ 6 ] Soto C. Mol . Med. Today , 1999 , 5 : 343 —349
|
| [25] | [ 7 ] Sabbagh M N , Galasko D L , Koo E W, et al . J . Alzheimer′sDis. , 2000 , 2 : 231 —259
|
| [26] | [ 8 ] Hutton M, Perez-Tur H J . Biochem. , 1998 , 33 : 117 —131
|
| [27] | Roher A E , Lowenson J D , Clarke S , et al . J . Biol . Chem. ,1993 , 268 : 3072 —3083
|
| [28] | Iwatsubo T, Odaka A , Suzuki N , et al . Neuron , 1994 , 13 : 45 —53
|
| [29] | Selkoe D S , Kodlinsky M B , Joachim H. J . Proc. Natl . Acad.Sci . USA , 1997 , 94 : 2095 —2097
|
| [30] | Joseph D B , Kang-Nian L , Yuxia L , et al . J . Bio. Chem. ,1998 , 273 : 27765 —27767
|
| [31] | Yan R , Bienkowski M, Shuck M, et al . Nature , 1999 , 402 :533 —537
|
| [32] | Lin X, Koolsch G, Wu S , Downs D , et al . Proc. Natl . Acad.Sci . USA , 2000 , 97 : 1456 —1460
|
| [33] | Vassar R , Bennett B D , Babu-Khan S , et al . Science , 1999 ,286 : 735 —741
|
| [34] | Fluhrer R , Capell A , Westmeyer G, et al . J . Neurochem. ,2002 , 81 : 1011 —1020
|
| [35] | Sinha S , Anderson J P , Barbour R , et al . Nature , 1999 , 402 :537 —40
|
| [36] | Marcinkeviciene J , Luo Y, Graciani N R , et al . Biol . Chem. ,2001 , 276 : 23790 —23794
|
| [37] | Ermolieff J , Loy J A , Koelsch G, et al . Biochemistry , 2000 , 39 :12450 —12456
|
| [38] | Roy K H , Larry Y F , Shumeye M, et al . J . Med. Chem. , 2003 ,46 : 1799 —1802
|
| [39] | Ramarishna N V S , Kumar E KS , Kulkarni A S , et al . Indian J .Chem. Sect . B : Org. Chem. Incl . Med. Chem. , 2001 , 40B :539 —540
|
| [40] | Kitazume S , Tachida Y, Oka R , et al . Proc. Natl . Acad. Sci .USA , 2001 , 98 : 13554 —13559
|
| [41] | Silvio R. Curr. Top. Med. Chem. , 2002 , 4 : 359 —370
|
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
