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化学进展  2006 

多环芳烃暴露的生物标志物——尿中羟基多环芳烃

, PP. 1381-1390

Keywords: 多环芳烃,羟基多环芳烃,生物标志物,尿样

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Abstract:

多环芳烃(PAHs)是典型的持久性有机污染物,在职业高PAHs暴露环境下,容易诱发肺癌、皮肤癌等癌症。对PAHs的暴露评价可为流行病学研究和污染物风险评价等提供有效的数据。由于暴露途径的复杂化,采用尿样中PAHs的代谢产物———羟基多环芳烃作为标志物来综合评价人体对PAHs的内暴露情况已经成为研究的热点。本文系统介绍了多环芳烃的吸收、代谢、尿中PAHs代谢产物的主要存在形式、主要的生物标志物以及它们的主要影响因素。

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