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化学进展  2014 

抗肿瘤药物输送系统

DOI: 10.7536/PC140308, PP. 1395-1408

Keywords: 抗肿瘤,药物输送系统,传统型,智能型,靶向型

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Abstract:

大多数小分子抗肿瘤药物均存在水溶性差、给药量大、体内半衰期短等问题,它们经口服或静脉注射给药后,只能通过自由扩散方式进入细胞,往往缺乏选择性,同时,对肿瘤细胞和正常细胞产生细胞毒性,具有较强的毒副作用,甚至对患者造成二次伤害。因此,它们在临床应用上受到很大限制。通过选择适宜的载体材料构筑抗肿瘤药物输送系统(如胶束、凝胶、纳米粒子等),不仅可以延长小分子抗肿瘤药物的半衰期、降低其毒副作用,而且还可提高其溶解性和生物利用度,因而受到广大科研人员及制药企业的广泛重视。到目前为止,抗肿瘤药物输送系统的发展历史已有60多年,大致可分为传统型、智能型和靶向型三个不同的发展阶段。本文将从这三个不同发展阶段来综述抗肿瘤药物输送系统及其最新的研究进展,并对其未来的发展进行展望。

References

[1]  Shen Y Q, Jin E, Zhang B, Murphy C J, Sui M H, Zhao J, Wang J Q, Tang J B, Fan M H, Kirk E V, Murdoch W J. J. Am. Chem. Soc., 2010, 132: 4259.
[2]  Danquah M K, Zhang X A, Mahato R I. Adv. Drug Deliv. Rev., 2011, 63: 623.
[3]  Liggins R T, Burt H M. Adv. Drug Deliv. Rev., 2002, 54: 191.
[4]  Gao G H, Li Y, Lee D S. J. Control. Release, 2013, 169: 180.
[5]  Goncalves M, Maciel D, Capelo D, Xiao S L, Sun W J, Shi X Y, Rodrigues J, Tomas H, Li Y L. Biomacromolecules, 2014, 15: 492.
[6]  Zheng J, Zhu G Z, Li Y H, Li C M, You M X, Chen T, Song E, Yang R H, Tan W H. ACS Nano, 2013, 7: 6545.
[7]  Naahidi S, Jafari M, Edalat F, Raymond K, Khademhosseini A, Chen P. J. Control. Release, 2013, 166: 182.
[8]  Xue X, Hall M D, Zhang Q, Wang P C, Gottesman M M, Liang X J. ACS Nano, 2013, 7: 10452.
[9]  张磊(Zang L), 刘晓燕(Liu X Y), 沈晶晶(Shen J J), 卢晓梅(Lu X M), 范曲立(Fan Q L), 黄维(Huang W). 化学进展(Prog. Chem.), 2013, 25: 1375.
[10]  Quadir M A, Haag R. J. Control. Release, 2012, 161: 484.
[11]  Bala V, Rao S, Boyd B J, Prestidge C A. J. Control. Release, 2013, 172: 48.
[12]  Shi J J, Votruba A R, Farokhzad O C, Langer R. Nano Lett., 2010, 10: 3223.
[13]  Zhang L, Gu F X, Chan J M, Wang A Z, Langer R S, Farokhzad O C. Clin. Pharmacol. Ther., 2008, 83: 761.
[14]  Zhang Y, Chan H F, Leong K W. Adv. Drug Deliv. Rev., 2013, 65: 104.
[15]  Park K. ACS Nano, 2013, 7: 7442.
[16]  Bui D T, Maksimenko A, Desmaёle D, Harrisson S, Vauthier C, Couvreur P, Nicolas J. Biomacromolecules, 2013, 14: 2837.
[17]  Chitkara D, Mittal A, Behrman S W, Kumar N, Mahato R I. Bioconjugate Chem., 2013, 24: 1161.
[18]  Wang H B, Wang Y, Chen Y J, Jin Q, Ji J. Polym. Chem., 2014, 5: 854.
[19]  Sun T M, Wang Y C, Wang F, Du J Z, Mao C Q, Sun C Y, Tang R Z, Liu Y, Zhu J, Zhu Y H, Yang X Z, Wang J. Biomaterials, 2014, 35: 836.
[20]  Cammas S, Suzuki K, Sone C, Sakurai Y, Kataoka K, Okano T. J. Control. Release, 1997, 48: 157.
[21]  Chung J E, Yokoyama M, Yamato M, Aoyagi T, Sakurai Y, Okano T. J. Control. Release, 1999, 62: 115.
[22]  Wei H, Wu D Q, Li Q, Chang C, Zhou J P, Zhang X Z, Zhuo R X. J. Phys. Chem. C, 2008, 112: 15329.
[23]  Loh X J, Wu Y L, Joseph S W T, Irzuan N M N, Zhang Z X, Xu F J, Kang E T, Neoh K G, Li J. Polymer, 2008, 49: 5084.
[24]  Kohori F, Sakai K, Aoyagi T, Yokoyama M, Sakurai Y, Okano T. J. Control. Release, 1998, 55: 87.
[25]  Loh X J, Zhang Z X, Wu Y L, Lee T S, Li J. Macromolecules, 2009, 42: 194.
[26]  Koning G A, Eggermont A M M, Lindner L H, ten Hagen T L M. Pharm. Res., 2010, 27: 1750.
[27]  Li L, ten Hagen T L M, Hossann M, Süss R, van Rhoon G C, Eggermont A M M, Haemmerich D, Koning G A. J. Control. Release, 2013, 168: 142.
[28]  Kuppusamy P, Li H Q, IIangovan G, Cardounel A J, Zweier J L, Yamada K, Krishna M C, Mitchell J B. Cancer Res., 2002, 62: 307.
[29]  Meng F H, Hennink W E, Zhong Z Y. Biomaterials, 2009, 30: 2180.
[30]  Ryu J H, Roy R, Ventura J, Thayumanavan S. Langmuir, 2010, 26: 7086.
[31]  Cheng R, Feng F, Meng F H, Deng C, Feijen J, Zhong Z Y. J. Control. Release, 2011, 152: 2.
[32]  Kakizawa Y, Harada A, Kataoka K. J. Am. Chem. Soc., 1999, 121: 11247.
[33]  Kakizawa Y, Harada A, Kataoka K. Biomacromolecules, 2001, 2: 491.
[34]  Oishi M, Hayama T, Akiyama Y, Takae S, Harada A, Yamasaki Y, Nagatsugi F, Sasaki S, Nagasaki Y, Kataoka K. Biomacromolecules, 2005, 6: 2449.
[35]  Liu J Y, Pang Y, Huang W, Zhu Z Y, Zhu X Y, Zhou Y F, Yan D Y. Biomacromolecules, 2011, 12: 2407.
[36]  Cao W, Zhang X L, Miao X M, Yang Z M, Xu H P. Angew. Chem. Int. Ed., 2013, 52: 6233.
[37]  Ma N, Xu H, An L, Li J, Sun Z, Zhang X. Langmuir, 2011, 27: 5874.
[38]  Zhang X, Wang C. Chem. Soc. Rev., 2011, 40: 94.
[39]  Ma N, Li Y, Xu H P, Wang Z Q, Zhang X. J. Am. Chem. Soc., 2010, 132: 442.
[40]  Chen L F, Wang W Q, Su B, Wen Y Q, Li C B, Zhou Y B, Li M Z, Shi X D, Du H W, Song Y L, Jiang L. ACS Nano, 2014, 8: 744.
[41]  Jana A, Devi K S, Maiti T K, Singh N D. J. Am. Chem. Soc., 2012, 134: 7656.
[42]  Goodwin A P, Mynar J L, Ma Y Z, Fleming G R, Fréchet J M J. J. Am. Chem. Soc., 2005, 127: 9952.
[43]  Liu G Y, Chen C J, Li D D, Wang S S, Ji J. J. Mater. Chem., 2012, 22: 16865.
[44]  Sun L, Ma X F, Dong C M, Zhu B S, Zhu X Y. Biomacromolecules, 2012, 13: 3581.
[45]  Chen G Y, Qiu H L, Prasad P N, Chen X Y. Chem. Rev., 2014, 114: 5161.
[46]  Wang C, Cheng L, Liu Z. Biomaterials, 2011, 32: 1110.
[47]  Xu H, Cheng L, Wang C, Ma X X, Li Y G, Liu Z. Biomaterials, 2011, 32: 9364.
[48]  Shen J, Zhao L, Han G. Adv. Drug Deliv. Rev., 2013, 65: 744.
[49]  Dai Y L, Xiao H H, Liu J H, Yuan Q H, Ma P A, Yang D M, Li C X, Cheng Z Y, Hou Z Y, Yang P P, Lin J. J. Am. Chem. Soc., 2013, 135: 18920.
[50]  Kim H, Lee D, Kim J, Kim T, Kim W J. ACS Nano, 2013, 7: 6735.
[51]  Tan S Y, Grimes S. Singapore Med. J., 2010, 51: 842.
[52]  Devadasu V R, Bhardwaj V, Ravi K M N V. Chem. Rev., 2013, 113: 1686.
[53]  Wu J H, Song C C, Jiang C X, Shen X, Qiao Q, Hu Y Q. Mol. Pharm., 2013, 10: 3555.
[54]  Miura Y, Takenaka T, Toh K, Wu S R, Nishihara H, Kano M R, Ino Y, Nomoto T, Matsumoto Y, Koyama H, Cabral H, Nishiyama N, Kataoka K. ACS Nano, 2013, 7: 8583.
[55]  Hariri G, Edwards A D, Merrill T B, Greenbaum J M, van der Ende A E, Harth E. Mol. Pharm., 2014, 11: 265.
[56]  Xu W J, Siddiqui I A, Nihal M, Pilla S, Rosenthal K, Mukhtar H, Gong S Q. Biomaterials, 2013, 34: 5244.
[57]  Guaragna A, Chiaviello A, Paolella C, D’Alonzo D, Palumbo G, Palumbo G. Bioconjugate Chem., 2012, 23: 84.
[58]  Nair B P, Vaikkath D, Nair P D. Langmuir, 2014, 30: 340.
[59]  Mackiewicz N, Nicolas J, Handké N, Noiray M, Mougin J, Daveu C, Lakkireddy H R, Bazile D, Couvreur P. Chem. Mater., 2014, 26: 1834.
[60]  Ladmiral V, Semsarilar M, Canton I, Armes S P. J. Am. Chem. Soc., 2013, 135: 13574.
[61]  Ding J X, Xiao C S, Li Y, Cheng Y L, Wang N N, He C L, Zhuang X L, Zhu X J, Chen X S. J. Control. Release, 2013, 169: 193.
[62]  Jiang X Y, Xin H L, Ren Q Y, Gu J J, Zhu L J, Du F Y, Feng C L, Xie Y K, Sha X Y, Fang X L. Biomaterials, 2014, 35: 518.
[63]  Liu Y, Gao F P, Zhang D, Fan Y S, Chen X G, Wang H. J. Control. Release, 2014, 173: 140.
[64]  Du C L, Deng D W, Shan L L, Wan S N, Cao J, Tian J M, Achilefu S, Gu Y Q. Biomaterials, 2013, 34: 3087.
[65]  Chen W Q, Zeng H M, Zheng R Q, Zhang S W, He J. Chin. J. Cancer Res., 2012, 24: 1.
[66]  Allen T M. Cullis P R. Science, 2004, 303: 1818.
[67]  Du W T, Hong L, Yao T W, Yang X C, He Q J, Yang B, Hu Y Z. Bioorg. Med. Chem., 2007, 15: 6323.
[68]  R?sler A, Vandermeulen G W M, Klok H A. Adv. Drug Deliv. Rev., 2012, 64: 270.
[69]  Deng C, Jiang Y J, Cheng R, Meng F H, Zhong Z Y. Nano Today, 2012, 7: 467.
[70]  Garofalo C, Capuano G, Sottile R, Tallerico R, Adami R, Reverchon E, Carbone E, Izzo L, Pappalardo D. Biomacromolecules, 2014, 15: 403.
[71]  Chang G T, Ci T Y, Yu L, Ding J D. J. Control. Release, 2011, 156: 21.
[72]  Joung Y K, Jang J Y, Choi J H, Han D K, Park K D. Mol. Pharm., 2013, 10: 685.
[73]  Zhang J X, Ma P X. Adv. Drug Deliv. Rev., 2013, 65: 1215.
[74]  Murugan E, Geetha R D P, Yogaraj V. Colloids Surf. B Biointerfaces, 2014, 114: 121.
[75]  Mignani S, El Kazzouli S, Bousmina M, Majoral J P. Adv. Drug Deliv. Rev., 2013, 65: 1316.
[76]  Bildstein L, Dubernet C, Couvreur P. Adv. Drug Deliv. Rev., 2011, 63: 3.
[77]  任天斌(Ren T B), 侠文娟(Xia W J), 吴畏(Wu W), 李永勇(Li Y Y). 化学进展(Prog. Chem.), 2013, 25: 775.
[78]  Farokhzad O C, Langer R. ACS Nano, 2009, 3: 16.
[79]  Wagner V, Dullaart A, Bock A K, Zweck A. Nat. Biotechnol., 2006, 24: 1211.
[80]  Bangham A D, Standish M M, Watkins J C. J. Mol. Biol., 1965, 13: 238.
[81]  Kim Y C, Park J H, Prausnitz M R. Adv. Drug Deliv. Rev., 2012, 64: 1547.
[82]  Ringsdorf H J. Polym. Sci. Polym. Symp., 1975, 51: 135.
[83]  Lutolf M P, Hubbell J A. Nat. Biotechnol., 2005, 23: 47.
[84]  Duncan R. Nat. Rev. Cancer, 2006, 6: 688.
[85]  Wang H B, Xu F M, Wang Y, Liu X S, Jin Q, Ji J. Polym. Chem., 2013, 4: 3012.
[86]  Yang Y Q, Zhao B, Li Z D, Lin W J, Zhang C Y, Guo X D, Wang J F, Zhang L J. Acta Biomater., 2013, 9: 7679.
[87]  Seki K, Tirrell D. Macromolecules, 1984, 17: 1692.
[88]  Ropert C, Lavignon M, Dubernet C, Couvreur P, Malvy C. Biochem. Biophys. Res. Commun., 1992, 183: 879.
[89]  Thomas J L, Tirrell D A. Acc. Chem. Res., 1992, 25: 336.
[90]  Martin T J, Procházka K, Munk P, Webber S E. Macromolecules, 1996, 29: 6071.
[91]  Bae Y, Fukushima S, Harada A, Kataoka K. Angew. Chem. Int. Ed., 2003, 42: 4640.
[92]  Zhang C Y, Yang Y Q, Huang T X, Zhao B, Guo X D, Wang J F, Zhang L J. Biomaterials, 2012, 33: 6273.
[93]  Koyamatsu Y, Hirano T, Kakizawa Y, Okano F, Takarada T, Maeda M. J. Control. Release, 2014, 173: 89.
[94]  Duan X P, Xiao J S, Yin Q, Zhang Z W, Yu H J, Mao S R, Li Y P. ACS Nano, 2013, 7: 5858.
[95]  She W C, Li N, Luo K, Guo C H, Wang G, Geng Y Y, Gu Z W. Biomaterials, 2013, 34: 2252.
[96]  Jin N X, Morin E A, Henn D M, Cao Y, Woodcock J W, Tang S C, He W, Zhao B. Biomacromolecules, 2013, 14: 2713.
[97]  张驰宇(Zhang C Y), 贺高红(He G H), 焉晓明(Yan X M), 段志军(Duan Z J). 功能材料(J. Funct. Mater.), 2010, 12: 2153.
[98]  Wang J, Liu C H, Shuai Y, Cui X Y, Nie L. Colloids Surf. B: Biointerfaces, 2014, 113: 223.
[99]  Scarpa J S, Mueller D D, Klotz I M. J. Am. Chem. Soc., 1967, 89: 6024.
[100]  Chung J E, Yokoyama M, Okano T. J. Control. Release, 2000, 65: 93.
[101]  Luo Y L, Yang X L, Xu F, Chen Y S, Zhang B. Colloids Surf. B: Biointerfaces, 2014, 114: 150.
[102]  Zhu Z C, Gao N, Wang H J, Sukhishvili S A. J. Control. Release, 2013, 171: 73.
[103]  Chang C, Wei H, Quan C Y, Li Y Y, Liu J, Wang Z C, Cheng S X, Zhang X Z, Zhuo R X. J. Polym. Sci. Part A: Polym. Chem., 2008, 46: 3048.
[104]  Moghadam M N, Kolesov V, Vogel A, Klok H A, Pioletti D P. Biomaterials, 2014, 35: 450.
[105]  Lin Z Q, Gao W, Hu H X, Ma K, He B, Dai W B, Wang X Q, Wang J C, Zhang X, Zhang Q. J. Control. Release, 2014, 174: 161.
[106]  Boustta M, Colombo P E, Lenglet S, Poujol S, Vert M. J. Control. Release, 2014, 174: 1.
[107]  May J P, Li S D. Recent Pat. Biomed. Eng., 2012, 5: 148.
[108]  Ta T, Porter T M. J. Control. Release, 2013, 169: 112.
[109]  May J P, Ernsting M J, Undzys E, Li S D. Mol. Pharm., 2013, 10: 4499.
[110]  Takae S, Miyata K, Oba M, Ishii T, Nishiyama N, Itaka K, Yamasaki Y, Koyama H, Kataoka K. J. Am. Chem. Soc., 2008, 130: 6001.
[111]  Dong W F, Kishimura A, Anraku Y, Chuanoi S, Kataoka K. J Am. Chem. Soc., 2009, 131: 3804.
[112]  Matsumoto S, Christie R J, Nishiyama N, Miyata K, Ishii A, Oba M, Koyama H, Yamasaki Y, Kataoka K. Biomacromolecules, 2009, 10: 119.
[113]  Thambi T, Yoon H Y, Kim K, Kwon I C, Yoo C K, Park J H. Bioconjugate Chem., 2011, 22: 1924.
[114]  Sun Y, Zou W, Bian S Q, Huang Y H, Tan Y F, Liang J, Fan Y J, Zhang X D. Biomaterials, 2013, 34: 6818.
[115]  Cui C, Xue Y N, Wu M, Zhang Y, Yu P, Liu L, Zhuo R X, Huang S W. Biomaterials, 2013, 34: 3858.
[116]  Page S M, Martorella M, Parelkar S, Kosif I, Emrick T. Mol. Pharm., 2013, 10: 2684.
[117]  Liu J Y, Pang Y, Huang W, Huang X H, Meng L L, Zhu X Y, Zhou Y F, Yan D Y. Biomacromolecules, 2011, 12: 1567.
[118]  Liu J Y, Huang W, Pang Y, Huang P, Zhu X Y, Zhou Y F, Yan D Y. Angew. Chem. Int. Ed., 2011, 50: 9162.
[119]  Ding Y, Yi Y, Xu H P, Wang Z Q, Zhang X. Chem. Commun., 2014, 50: 2585.
[120]  Xu H P, Cao W, Zhang X. Acc. Chem. Res., 2013, 46: 1647.
[121]  Fu Y, Chen J Y, Xu H P, Oosterwijck C V, Zhang X, Dehaen W, Smet M. Macromol. Rapid Commun., 2012, 33: 798.
[122]  Liu J Y, Pang Y, Chen J, Huang P, Huang W, Zhu X Y, Yan D Y. Biomaterials, 2012, 33: 7765.
[123]  Wang G, Tong X, Zhao Y. Macromolecules, 2004, 37: 8911.
[124]  Jiang J Q, Tong X, Zhao Y. J. Am. Chem. Soc., 2005, 127: 8290.
[125]  Li Y M, Qian Y F, Liu T, Zhang G Y, Liu S Y. Biomacromolecules, 2012, 13: 3877.
[126]  Lin H M, Wang W K, Hsiung P A, Shyu S G. Acta Biomater., 2010, 6: 3256.
[127]  Yang J, He W D, He C, Tao J, Chen S Q, Niu S M, Zhu S L. J. Polym. Sci. Part A: Polym. Chem., 2013, 51: 3791.
[128]  Guardado-Alvarez T M, Sudha D L, Russell M M, Schwartz B J, Zink J I. J. Am. Chem. Soc., 2013, 135: 14000.
[129]  Cao J, Huang S S, Chen Y Q, Li S W, Li X, Deng D W, Qian Z Y, Tang L P, Gu Y Q. Biomaterials, 2013, 34: 6272.
[130]  Zhang P, Steelant W, Kumar M, Scholfield M. J. Am. Chem. Soc., 2007, 129: 4526.
[131]  Miao D Y, Jiang M Y, Liu Z Y, Gu G Z, Hu Q Y, Kang T, Song Q X, Yao L, Li W, Gao X L, Sun M J, Chen J. Mol. Pharm., 2014, 11: 90.
[132]  Tang J, Zhang L, Liu Y Y, Zhang Q Y, Qin Y, Yin Y J, Yuan W M, Yang Y T, Xie Y F, Zhang Z R, He Q. Int. J. Pharm., 2013, 454: 31.
[133]  Li X, Zhao Q H, Qiu L Y. J. Control. Release, 2013, 171: 152.
[134]  Fan J Q, Zeng F, Wu S Z, Wang X D. Biomacromolecules, 2012, 13: 4126.
[135]  Santra S, Kaittanis C, Santiesteban O J, Perez J M. J. Am. Chem. Soc., 2011, 133: 16680.
[136]  El-Gogary R I, Rubio N, Wang J T W, Al-Jamal W T, Bourgognon M, Kafa H, Naeem M, Klippstein R, Abbate V, Leroux F, Bals S, Tendeloo G V, Kamel A O, Awad G A S, Mortada N D, Al-Jamal K T. ACS Nano, 2014, 8: 1384.
[137]  Guo X, Shi C L, Wang J, Di S B, Zhou S B. Biomaterials, 2013, 34: 4544.
[138]  Yang Z G, Lee J H, Jeon H M, Han J H, Park N, He Y X, Lee H, Hong K S, Kang C, Kim J S. J. Am. Chem. Soc., 2013, 135: 11657.
[139]  Zhao F, Yin H, Li J. Biomaterials, 2014, 35: 1050.

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