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OALib Journal期刊
ISSN: 2333-9721
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过氧亚硝酸根对蛋白质损伤的研究进展*
, PP. 893-901
Keywords: 过氧亚硝酸根,蛋白质,分子机理,病理
Abstract:
过氧亚硝酸根--一氧化氮和超氧根阴离子快速结合的产物，是生物体内产生的一种强氧化剂和细胞毒性物质，它可以介导生物大分子包括DNA、蛋白质和脂质的修饰和损伤。近年来，由于许多疾病条件下都发现大量过氧亚硝酸根诱导的蛋白质损伤产物，因此过氧亚硝酸根与蛋白质的相互作用引起了人们的广泛关注。本文详尽地介绍了过氧亚硝酸根介导蛋白质损伤对人体的病理作用和过氧亚硝酸根与蛋白质作用机制等方面的最新研究进展，并对未来过氧亚硝酸根与蛋白质相互作用的研究作了展望。
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