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化学进展  2009 

金属抗癌药物设计的新策略和新趋势*

, PP. 845-855

Keywords: 金属配合物,抗癌药物,毒副反应,设计策略

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Abstract:

金属药物有许多其它药物无法比拟的独特性质，以顺铂为代表的铂类抗癌药物在癌症临床化疗中发挥了巨大作用。但是铂类药物的毒副作用严重限制了它们的实际疗效和适用范围，因此需要继续研究具有不同作用机理的新型金属抗癌药物，以改良或补充现有铂类药物的性能。本文重点介绍了近年来设计金属抗癌药物的一些新策略，包括改变铂类药物与DNA的作用模式、改进铂类药物对肿瘤的靶向性、研发非铂类金属抗癌药物和寻找DNA以外的作用靶标等。这些内容体现了该领域的最新发展趋势，为从事金属抗癌药物开发研究的科技人员提供了有益的参考信息。

 References

[1]  [56 ] 　Dyson P J , Sava G. Dalton Trans. , 2006 , 1929 —1933
[2]  [57 ] 　Bergamo A , Sava G. Dalton Trans. , 2007 , 1267 —1272
[3]  [58 ] 　Scolaro C , Bergamo A , Brescacin L , et al . J . Med. Chem. , 2005 ,48 : 4161 —4171
[4]  [59 ] 　Habtemariam A , Melchart M, Fernández R , et al . J . Med. Chem. ,2006 , 49 : 6858 —6868
[5]  [60 ] 　Yan Y K, Melchart M, Habtemariam A , et al . Chem. Commun. ,2005 , 4764 —4776
[6]  [61 ] 　Liu H K, Berners-Price S J , Wang F Y, et al . Angew. Chem. Int .Ed. , 2006 , 45 : 8153 —8156
[7]  [62 ] 　Peacock A F A , Parsons S , Sadler PJ . J . Am. Chem. Soc. , 2007 ,129 : 3348 —3357
[8]  [63 ] 　Friebolin W, Schilling G, Zê ller M, et al . J . Med. Chem. , 2005 ,48 : 7925 —7931
[9]  [64 ] 　Sun R W Y, Ma D L , Wong E L M, et al . Dalton Trans. , 2007 ,4884 —4892
[10]  [65 ] 　Wang X Y, Guo ZJ . Dalton Trans. , 2008 , 1521 —1532
[11]  [66 ] 　Shi P F , Jiang Q , Zhao Y M, et al . J . Biol . Inorg. Chem. , 2006 ,11 : 745 —752
[12]  [67 ] 　Yang T, Tu C , Zhang J Y, et al . Dalton Trans. , 2003 , 3419 —3424
[13]  [68 ] 　Shi P F , Jiang Q , Lin J , et al . J . Inorg. Biochem. , 2006 , 100 :939 —945
[14]  [69 ] 　Wang X Y, Zhang X M, Lin J , et al . Dalton Trans. , 2003 , 2379 —2380
[15]  [70 ] 　Zhang S C , Tu C , Wang X Y, et al . Eur. J . Inorg. Chem. , 2004 ,4028 —4035
[16]  [71 ] 　Chen Z F , Wang X Y, Zhu Y G, et al . J . Inorg. Biochem. , 2007 ,101 : 1894 —1902
[17]  [72 ] 　Schatzschneider U , Metzler-Nolte N. Angew. Chem. Int . Ed. ,2006 , 45 : 1504 —1507
[18]  [73 ] 　Hillard E , Vessières A , Thouin L , et al . Angew. Chem. Int . Ed. ,2006 , 45 : 285 —290
[19]  [74 ] 　James P , Neudêrfl J , Eissmann M, et al . Org. Lett . , 2006 , 8 :2763 —2766
[20]  [75 ] 　Strohfeldt K, Tacke M. Chem. Soc. Rev. , 2008 , 37 : 1174 —1187
[21]  [76 ] 　Koch B , Baul T S B , Chatterjee A. J . Appl . Toxicol . , 2008 , 28 :430 —438
[22]  [77 ] 　Meggers E , Atilla-Gokcumen G E , Bregman H , et al . Synlett ,2007 , 1177 —1189
[23]  [78 ] 　Bregman H , Carroll P J , Meggers E. J . Am. Chem. Soc. , 2006 ,128 : 877 —884
[24]  [79 ] 　Smalley K S M, Contractor R , Haass N K, et al . Cancer Res. ,2007 , 67 : 209 —217
[25]  [80 ] 　Reed J E , Arnal A A , Neidle S , et al . J . Am. Chem. Soc. , 2006 ,128 : 5992 —5993
[26]  [81 ] 　Dixon I M, Lopez F , Tejera A M, et al . J . Am. Chem. Soc. ,2007 , 129 : 1502 —1503
[27]  [82 ] 　Kieltyka R , Fakhoury J , Moitessier N , et al . Chem. Eur. J . ,2008 , 14 : 1145 —1154
[28]  [83 ] 　Kieltyka R , Englebienne P , Fakhoury J , et al . J . Am. Chem.Soc. , 2008 , 130 : 10040 —10041
[29]  [84 ] 　Pennington J D , Jacobs KM, Sun L , et al . Curr. Pharm. Design ,2007 , 13 : 3368 —3377
[30]  [85 ] 　Urig S , Fritz-Wolf K, Réau R , et al . Angew. Chem. Int . Ed. ,2006 , 45 : 1881 —1886
[31]  [86 ] 　Barnard P J , Berners-Price S J . Coord. Chem. Rev. , 2007 , 251 :1889 —1902
[32]  [87 ] 　Wang Y, He Q Y, Che CM, et al . Proteomics , 2006 , 6 : 131 —142
[33]  [88 ] 　Ott I , Schmidt K, Kircher B , et al . J . Med. Chem. , 2005 , 48 :622 —629
[34]  [89 ] 　Failes TW, Cullinane C , Diakos C I , et al . Chem. Eur. J . , 2007 ,13 : 2974 —2982
[35]  [90 ] 　Timerbaev A R , Hartinger C G, Aleksenko S S , et al . Chem.Rev. , 2006 , 106 : 2224 —2248
[36]  [91 ] 　Calderone V , Casini A , Mangani S , et al . Angew. Chem. Int .Ed. , 2006 , 45 : 1267 —1269
[37]  [92 ] 　Casini A , Mastrobuoni G, Ang W H , et al . Chem. Med. Chem. ,2007 , 2 : 631 —635
[38]  [93 ] 　Weidt S K, Mackay C L , Langridge-Smith P R R , et al . Chem.Commun. , 2007 , 1719 —1721
[39]  [94 ] 　Hartinger C G, Tsybin YO , Fuchser J , et al . Inorg. Chem. , 2008 ,47 : 17 —19
[40]  [ 1 ] 　Kelland L. Nature Rev. Cancer , 2007 , 7 : 573 —584
[41]  [ 3 ] 　Hambley T W. Dalton Trans. , 2007 , 4929 —4937
[42]  [ 2 ] 　Galanski M, Jakupec M A , Keppler B K. Curr. Med. Chem. ,2005 , 12 : 2075 —2094
[43]  [ 4 ] 　Gielen M, Tiekink E R T. Metallotherapeutic Drugs and Metal-based Diagnostic Agents -the Use of Metals in Medicine. Chichester : John Wiley &Sons , Ltd. , 2005
[44]  [ 5 ] 　Pérez J M, Fuertes M A , Alonso C. Metal Compounds in Cancer Chemotherapy. Kerala : Research Signpost , 2005
[45]  [ 6 ] 　Momekov G, Momekova D. Expert . Opin. Ther. Patents , 2006 ,16 : 1383 —1403
[46]  [ 7 ] 　Bruijnincx P C A , Sadler P J . Curr. Opin. Chem. Biol . , 2008 ,12 : 197 —206
[47]  [ 8 ] 　Argyriou A A , Polychronopoulos P , Iconomou G, et al . Cancer Treat . Rev. , 2008 , 34 : 368 —377
[48]  [ 9 ] 　McWhinney S R , Goldberg RM, McLeod HL. Mol . Cancer Ther. ,2009 , 8 : 10 —16
[49]  [10 ] 　Pasetto L M, D’Andrea M R , Rossi E , et al . Crit . Rev. Oncol .Hemat . , 2006 , 59 : 159 —168
[50]  [11 ] 　Rabik C A , Dolan M E. Cancer Treat . Rev. , 2007 , 33 : 9 —23
[51]  [12 ] 　Wang X Y, Guo Z J . Anti-Cancer Agents Med. Chem. , 2007 , 7 :19 —34
[52]  [13 ] 　Kalinowska-Lis U , Ochocki J , Matlawska-Wasowska K. Coord.Chem. Rev. , 2008 , 252 : 1328 —1345
[53]  [14 ] 　Abu-Surrah A S. Mini-Rev. Med. Chem. , 2007 , 7 : 203 —211
[54]  [15 ] 　Kostova I. Curr. Med. Chem. , 2006 , 13 : 1085 —1107
[55]  [16 ] 　Hartinger C G, Zorbas-Seifried S , Jakupec M A , et al . J . Inorg.Biochem. , 2006 , 100 : 891 —904
[56]  [17 ] 　Jakupec M A , Galanski M, Arion V B , et al . Dalton Trans. , 2008 ,183 —194
[57]  [18 ] 　Casini A , Cinellu MA , Minghetti G, et al . J . Med. Chem. , 2006 ,49 : 5524 —5531
[58]  [19 ] 　Suresh D , Balakrishna M S , Rathinasamy K, et al . Dalton Trans. ,2008 , 2812 —2814
[59]  [20 ] 　Huang R , Wallqvist A , Covell D G. Biochem. Pharmacol . , 2005 ,69 : 1009 —1039
[60]  [21 ] 　Li H , Lai C S , Wu J , et al . J . Inorg. Biochem. , 2007 , 101 :809 —816
[61]  [22 ] 　Wang G C , Xiao J , Lu Y N , et al . Appl . Organometal . Chem. ,2005 , 19 : 113 —117
[62]  [23 ] 　Wang T, Guo ZJ . Curr. Med. Chem. , 2006 , 13 : 525 —537
[63]  [24 ] 　Ott I , Gust R. Arch. Pharm. Chem. Life Sci . , 2007 , 340 : 117 —126
[64]  [25 ] 　Afrasiabi Z, Sinn E , Lin W, et al . J . Inorg. Biochem. , 2005 , 99 :1526 —1531
[65]  [26 ] 　Matkar S S , Wrischnik L A , Jones P R , et al . Biochem. Biophys.Res. Commun. , 2006 , 343 : 754 —761
[66]  [27 ] 　Wang D , Lippard SJ . Nature Rev. Drug Dis. , 2005 , 4 : 307 —320
[67]  [28 ] 　Jung Y, Lippard S J . Chem. Rev. , 2007 , 107 : 1387 —1407
[68]  [29 ] 　Coluccia M, Natile G. Anti-Cancer Agents Med. Chem. , 2007 , 7 :111 —123
[69]  [30 ] 　Coley H M, Sarju J , Wagner G. J . Med. Chem. , 2008 , 51 : 135 —141
[70]  [31 ] 　Zhang J Y, Wang X Y, Tu C , et al . J . Med. Chem. , 2003 , 46 :3502 —3507
[71]  [32 ] 　Gao X L , Wang X Y, Ding J , et al . Inorg. Chem. Commun. ,2006 , 9 : 722 —726
[72]  [33 ] 　Wang X Y, Lin J , Zhang X M, et al . J . Inorg. Biochem. , 2003 ,94 : 186 —192
[73]  [34 ] 　Martins E T, Baruah H , Kramarczyk J , et al . J . Med. Chem. ,2001 , 44 : 4492 —4496
[74]  [35 ] 　Brow J M, Pleatman C R , Bierbach U. Bioorg. Med. Chem. Lett . ,2002 , 12 : 2953 —2955
[75]  [36 ] 　Baruah H , Rector CL , Monnier SM, et al . Biochem. Pharmacol . ,2002 , 64 : 191 —200
[76]  [37 ] 　Lovejoy K S , Todd R C , Zhang S , et al . Proc. Natl . Acad. Sci .USA , 2008 , 105 : 8902 —8907
[77]  [38 ] 　Zhao Y M, He WJ , Shi P F , et al . Dalton Trans. , 2006 , 2617 —2619
[78]  [39 ] 　Fan D M, Yang X L , Wang X Y, et al . J . Biol . Inorg. Chem. ,2007 , 12 : 655 —665
[79]  [40 ] 　Komeda S , Moulaei T, Woods K K, et al . J . Am. Chem. Soc. ,2006 , 128 : 16092 —16103
[80]  [41 ] 　Harris A L , Yang X, Hegmans A , et al . Inorg. Chem. , 2005 , 44 :9598 —9600
[81]  [42 ] 　Van Zutphen S , Reedijk J . Coord. Chem. Rev. , 2005 , 249 :2845 —2853
[82]  [43 ] 　Yang Z, Wang X Y, Diao H J , et al . Chem. Commun. , 2007 ,3453 —3455
[83]  [44 ] 　MacDiarmid J A , Mugridge N B , Weiss J C , et al . Cancer Cell ,2007 , 11 : 431 —445
[84]  [45 ] 　Hall MD , Mellor H R , Callaghan R , et al . J . Med. Chem. , 2007 ,50 : 3403 —3411
[85]  [46 ] 　Ang W H , Khalaila I , Allardyce C S , et al . J . Am. Chem. Soc. ,2005 , 127 : 1382 —1383
[86]  [47 ] 　Feazell R P , Nakayama-Ratchford N , Dai H , et al . J . Am. Chem.Soc. , 2007 , 129 : 8438 —8439
[87]  [48 ] 　Ronconi L , Sadler P J . Coord. Chem. Rev. , 2007 , 251 : 1633 —1648
[88]  [49 ] 　Bednarski P J , Grünert R , Zielzki M, et al . Chem. Biol . , 2006 ,13 : 61 —67
[89]  [50 ] 　Mackay F S , Woods J A , Moseley H , et al . Chem. Eur. J . , 2006 ,12 : 3155 —3161
[90]  [51 ] 　Mackay F S , Woods J A , HeringováP , et al . Proc. Natl . Acad.Sci . USA , 2007 , 104 : 20743 —20748
[91]  [52 ] 　Mao J F , Zhang Y M, Zhu J H , et al . Chem. Commun. , 2009 ,908 —910
[92]  [53 ] 　Heringova P , Woods J , Mackay F S , et al . J . Med. Chem. , 2006 ,49 : 7792 —7798
[93]  [54 ] 　Hannon MJ . Pure Appl . Chem. , 2007 , 79 : 2243 —2261
[94]  [55 ] 　Ang W H , Dyson P J . Eur. J . Inorg. Chem. , 2006 , 4003 —4018

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