全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
化学进展  2010 

99mTc标记的叶酸肿瘤显像剂*

, PP. 603-609

Keywords: 叶酸受体,叶酸,99mTc,放射性药物,肿瘤显像

Full-Text   Cite this paper   Add to My Lib

Abstract:

叶酸受体在许多源于上皮组织的恶性肿瘤中高度表达,是目前肿瘤放射性显像研究的一个新的靶点。由于叶酸对于叶酸受体具有很高的亲和性,作为重要的特异性靶向介导分子,99mTc标记叶酸肿瘤显像剂已成为当前放射性药物的研究热点之一。本文对不同类型的99mTc标记的叶酸类放射性肿瘤显像剂的研究进展、应用情况和存在的问题进行了评述,探讨了99mTc标记叶酸显像剂的一般设计方法,并对其未来发展方向进行了展望。

References

[1]  [3 ] Hilgenbrink A R,Low P S. J. Pharm. Sci. ,2005,94: 2135—2146
[2]  [5 ] Ke C Y,Mathias C J,Green M A. Adv. Drug Deliv. Rev. ,2004,56: 1143—1160
[3]  [6 ] Gucalp R,Dutcher J,Wiernik P H. Semin. Nucl. Med. ,1997,27: 3—9
[4]  [7 ] Elnakat H,Ratnam M. Adv. Drug Deliv. Rev. ,2004,56:1067—1084
[5]  [8 ] Sudimack J,Lee R J. Adv. Drug Deliv. Rev. ,2000,41:147—162
[6]  Ross T L,Honer M,Schibli R. Bioconjugate Chem. ,2008,19:2462—2470
[7]  Leamon C P,Low P S. Biochem. J. ,1993,291: 855—860
[8]  Mathias C J,Wang S,Lee R J,et al. J. Nucl. Med. ,1996,37: 1003—1008
[9]  Wang S,Lee R J,Low P S,et al. Bioconjugate Chem. ,1996,7: 56—62
[10]  Mathias C J,Hubers D,Low P S,et al. Bioconjugate Chem. ,2002,11: 253—257
[11]  Mathias C J,Wang S,Water D J,et al. J. Nucl. Med. ,1998,39: 1579—1585
[12]  Ross T L, Honer M, Ametamey S M, et al. Bioconjugate Chem. ,2008,19: 2462—2470
[13]  Bettio A,Honer M,Muller C,et al. J. Nucl. Med. ,2006,47:1153—1160
[14]  Trump D P,Mathias C J,Yang Z F,et al. Nucl. Med. Biol. ,2002,29: 569—573
[15]  Müller C,Dumas C,Schibli R,et al. J. Organomet. Chem. ,2004,689: 4712—4721
[16]  Müller C,Hohn A,Schibli R,et al. Eur. J. Nucl. Med. Mol.Imaging,2006,33: 1007—1016
[17]  Müller C,Schubiger P A,Schibli R. Nucl. Med. Biol. ,2007,34: 595—601
[18]  Müller C, Schubiger P A, Schibli R. Bioconjugate Chem. ,2006,17: 797—806
[19]  Struthers H,Spingler B,Mindt T L,et al. Chem. Eur. J.2008,14: 6173—6183
[20]  Müller C,Forrer F,Schibli R,et al. J. Nucl. Med. ,2008,49: 310—317
[21]  Reddy J A,Xu L C,Parker N,et al. J. Nucl. Med. ,2004,45: 857—866
[22]  Sega E I,Low P S. Cancer Metastasis Rev. ,2008,27: 655—664
[23]  Okarvi S M,Jammaz I A. Cancer Biother. Radiopharm. ,2006,21: 49—61
[24]  胡春林(Hu C L) ,崔海平( Cui H P) ,杜进( Du J) . 核化学与放射化学( Journal of Nuclear and Radiochemisty ) ,2007,29: 231—237
[25]  Wedeking P W, Wager R E, Arunachalam T, et al. US 6221334,2001
[26]  Guo W,Hinkle G H,Lee R J. J. Nucl. Med. ,1999,40:1563—1569
[27]  刘丽琴( Liu L Q) ,王世真(Wang S Z) ,李方( Li F) 等. 中国医学科学院学报( Acta Acad. Med. Sin. ) ,2006,28: 786—789
[28]  万丹晶(Wan D J) ,钟高仁( Zhong G R) ,朱建华( Zhu J H)等. 核技术(Nuclear Techiniques) ,2004,27: 293—296
[29]  Lui M,Xu W,Xu L J,et al. Bioconjugate chem. ,2005,16:1126—1132
[30]  [1 ] Sudimack J,Lee R J. Adv. Drug Deliv. Rev. ,2000,41147—162
[31]  [2 ] Ke C Y,Mathias C J,Green M A. Nucl. Med. Biol. ,2003,30: 811—817
[32]  [4 ] Leamon C P,Low P S. Drug Discovery Today,2001,6: 44—51
[33]  [9 ] Low P S,Antony A C. Adv. Drug Deliv. Rev. ,2004,56:1055—1058
[34]  Maziarz K M,Monaco H L,Ratnam M. J. Biol. Chem. ,1999,274: 11086—11901
[35]  Ke C Y,Mathias C J,Green M A. J. Am. Chem. Soc. ,2005,127: 7421—7426
[36]  Wang S,Lou J,Lantrip D A,et al. Bioconjugate Chem. ,1997,8: 673—679
[37]  Wang S,Luo J,Low P S. Bioconjugate Chem. ,1997,8: 673—679
[38]  Alberto R,Schibli R,Kaden T A. J. Am. Chem. Soc. ,1998,120: 7987—7988
[39]  Mindt T L,Struthers H,Schibli R,et al. J. Am. Chem. Soc. ,2006,128: 15096—15097
[40]  Mindt T L,Müller C,Schibli R,et al. Bioconjugate Chem. ,2008,19: 1689—1695
[41]  刘伯里( Liu B L) ,贾红梅( Jia H M) . 锝药物化学及其应用( Technetium Radiopharmaceutical Chemistry and Its Applications) . 北京: 北京师范大学出版社( Beijing: Beijing Normal University Press) ,2006. 84—94
[42]  Leamon C P,Parker M A,Vlahov I R,et al. Bioconjugate Chem. ,2002,13: 1200—1210
[43]  Wedeking P W, Wager R E, Arunachalam T, et al. US 6093382,2000
[44]  Llgan S, Yang D J, Higuch T, et al. Cancer Biother.Radiopharm. ,1995,13: 427—435
[45]  Decristoforo C,Mather S J. Nucl. Med. Biol. ,1999,26:389—396
[46]  Mathias C J,Hubers D,Low P S,et al. Bioconjugate Chem. ,2000,11: 253—257
[47]  Leamon C P,You F,Krishna H. Pharm. Res. ,2009,26:1315—1323
[48]  Shen Y, Zhang Y, Sun Y, et al. J. Label. Comp.Radiopharm. ,2009,52( S1) : S101—S116
[49]  Müller C,Schibli R,Forrer F,et al. Nucl. Med. Biol. ,2007,34: 603—608
[50]  Müller C,Schibli R,Krenning E P,et al. J. Nucl. Med. ,2008,49: 623—629
[51]  Müller C,Mindt T L,Schibli R,et al. Eur. J. Nucl. Med.Mol. Imaging,2009,36: 938—946

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133