全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
化学进展  2010 

原癌基因c-myc启动区G-四链体结构及靶向小分子配体*

, PP. 983-992

Keywords: 原癌基因c-myc,G-四链体,NMR,小分子配体

Full-Text   Cite this paper   Add to My Lib

Abstract:

随着DNAG-四链体结构的发现和现代分子生物学技术对其与癌症关系的揭示,DNAG-四链体逐渐成为抗肿瘤药物研究的新靶点。c-myc启动区G-四链体由于在细胞生长、增殖、凋亡、衰老及肿瘤形成等过程中的重要作用,成为DNAG-四链体中最受关注的序列之一。本文旨在对c-myc启动区G-四链体的结构及靶向c-mycG-四链体的小分子配体的研究进展进行综述。首先,介绍c-mycG-四链体的生物学意义;其次,对几种常用的c-mycG-四链体的结构进行解析;最后,对以c-myc为靶点的小分子配体的研究进展及其与G-四链体的作用模式进行综述,并对目前以c-mycG-四链体为靶点、已经走向临床实验的CX-3543的开发与作用机制进行介绍。

References

[1]  33: 2901—2907
[2]  [3 ] Verdun R E,Karlseder J. Nature,2007,447: 924—930
[3]  [4 ] Dash J,Shirude P S,Hsu S D,Balasubramanian S. J. Am.
[4]  [5 ] Hurley L H,von Hoff D D,Siddiqui-Jain A,Yang D. Semin.
[5]  Oncol. ,2006,33: 498—512
[6]  Soc. ,2004,126: 8702—8709
[7]  [8 ] Sun D,Guo K,Rusche J J,et al. Nucleic Acids Res. ,2005,
[8]  33: 6070—6080
[9]  16341—16350
[10]  2006,128: 5404—5415
[11]  Fernando H,Reszka A P,Huppert J, et al. Biochemistry,
[12]  2006,45: 7854—7860
[13]  Phan A T,Kuryavyi A,Burge S,et al. J. Am. Chem. Soc. ,
[14]  2007,129: 4386—4392
[15]  2007,129: 7484—7485
[16]  Todd A K,Haider S M,Parkinson G N,et al. Nucleic Acids
[17]  Mergny J L,Helene L. Nat. Med. ,1998,4: 1366—1367
[18]  Zhou Q J,Li L,Xiang J F,et al. Angew. Chem. Int. Ed. ,
[19]  2008,47: 5590—5592
[20]  2009,1103—1105
[21]  Zhang X F,Xiang J F,Sun H X,et al. J. Phys. Chem. B,
[22]  2009,113: 7662—7667
[23]  Yang Q F,Xiang J F,Li Q,et al. J. Phys. Chem. B,2008,
[24]  112: 8783—8787
[25]  308
[26]  819
[27]  Sun H X,Xiang J F,Zhang Y Z,et al. Chin. Sci. Bull. ,
[28]  2006,51: 1022—1026
[29]  Sun H X,Xiang J F,Tang Y L,et al. Biochem. Biophys. Res.
[30]  张秀凤( Zhang X F) ,向俊锋(Xiang J F) ,田明月( Tian M Y)
[31]  吕小伟( Lv X W) ,朱驹( Zhu J) ,周有骏( Zhou Y J) . 国外医
[32]  学: 药学分册( Foreign Medical Sciences ( Section of
[33]  1992,61: 809—860
[34]  Dev. ,2000,10: 100—105
[35]  Pelengaris S,Khan M. Arch. Biochem. Biophys. ,2003,416:
[36]  48
[37]  Sakatsume O,Tsutsui H,Wang Y,et al. Journal of Biological
[38]  Chemistry,1996,127: 31322—31333
[39]  Cooney M,Czernuszewicz G,Postel E H,et al. Science,1988,
[40]  Siebenlist U,Henninghausen L,Battey J,et al. Cell,1984,
[41]  Zhang N,Phan A T,Patel D. J. Am. Chem. Soc. ,2005,
[42]  127: 17277—17285
[43]  2007,6(12) : 3462S—3463S
[44]  Rangan A,Fedoroff O Y,Hurley L H. J. Biol. Chem. ,2001,276: 4640—4646
[45]  33(18) : 6070—6080
[46]  Kato G J,Barrett J. Mol. Cell. Biol. ,1990,10: 5914—5920
[47]  Sci. USA,2004,101: 6140—6145
[48]  Grand C L,Han H,Munoz R M,et al. Mol. Cancer Ther. ,
[49]  2002,1: 565—573
[50]  Ou T M,Lu Y J,Zhang C,et al. J. Med. Chem. ,2007,50:
[51]  1465—1474
[52]  Phan A T,Modi Y S,Patel D J. J. Am. Chem. Soc. ,2004,
[53]  126: 8710—8716
[54]  Da-Silva M W. Methods,2007,43: 264—277
[55]  Lemarteleur T,Gomeza D,Paterskia R,et al. Biochemical and
[56]  Biophysical Research Communications,2004,323: 802—808
[57]  Ambrus A,Chen D,Dai J,et al. Biochemistry,2005,44:
[58]  2048—2058
[59]  Papadopoulos K,Mita A,Ricart A,et al. Mol. Cancer Ther. ,
[60]  Borman S. Chem. Eng. News,2007,85 (22) : 12—17
[61]  Kerwin S M,Chen G,Kern J T,et al. Bioorg. Med. Chem.
[62]  Lett. ,2002,12: 447—450
[63]  Sun D,Guo K,Rusche J J,et al. Nucleic Acids Res. ,2005,
[64]  Maiti S, Chaudhury N K, Chowdhury S. Biochemical and
[65]  Biophysical Research Communications,2003,310: 505—512
[66]  Ou T M,Lu Y J,Tan J H,et al. Chemmedchem,2008,3(5) :
[67]  690—713
[68]  Gabelica V,Baker E S,Teulade-Fichou M P,et al. J. Am.Chem. Soc. ,2007,129: 895—904
[69]  [1 ] Qin Y,Hurley L H. Biochimie,2008,90: 1149—1171
[70]  [2 ] Todd A K,Johnston M,Neidle S. Nucleic Acids Res. ,2005,
[71]  Chem. Soc. ,2008,130: 15950—15956
[72]  [6 ] Tian M Y,Zhang X F,Li Y,Ju Y,Xiang J F,Zhao C Q,Tang
[73]  Y L. Nucleosides,Nucleotides and Nucleic Acids,2010,29:
[74]  190—199
[75]  [7 ] Seenisamy J,Rezler E M,Powell T J,et al. J. Am. Chem.
[76]  [9 ] Armond R D,Wood S,Sun D,et al. Biochemistry,2005,44:
[77]  Cogoi S,Xodo L E. Nucleic Acids Res. ,2006,34: 2536—
[78]  2549
[79]  Dexheimer T S,Sun D,Hurley L H. J. Am. Chem. Soc. ,
[80]  Dai J,Chen D,Jones R A,et al. Nucleic Acids Res. ,2006,
[81]  34: 5133—5144
[82]  Rankin S,Reszka A P,Huppert J,et al. J. Am. Chem. Soc. ,
[83]  2005,127: 10584—10589
[84]  Shirude P S,Okumus B,Ying L,et al. J. Am. Chem. Soc. ,
[85]  Res. ,2007,35: 5799—5808
[86]  Qin Y,Rezler E M,Gokhale V,et al. Nucleic Acids Res. ,
[87]  2007,25: 7698—7713
[88]  Yang Q F,Xiang J,Yang S,et al. Chemical Communications,
[89]  Zhou Q J,Li L,Xiang J F,et al. Biochimie,2008,91: 304—
[90]  Li Q,Xiang J F,Li X D,et al. Biochimie,2009,91: 811—
[91]  Commun. ,2007,352: 942—946
[92]  Sun H X,Tang Y L,Xiang J F. Bioorg. Med. Chem. Lett. ,
[93]  2006,16: 3586—3589
[94]  等. 科学通报( Sci. Bull. ) ,2009,54(10) : 1374 —1386
[95]  陆涛( Lu T) ,韩海泳( Han H Y) 等. 药学进展( Progress of
[96]  China Pharmaceutical Sciences) ,2001,5: 65—70
[97]  Pharmarcy) ) ,2004,31: 333—337
[98]  Pivetta C, Lucatello L, Krapcho A P, et al. Bioorganic &
[99]  Medicinal Chemistry,2008,16: 9331—9339
[100]  Seenisamy J,Bashyam S,Gokhale V,et al. J. Am. Chem.
[101]  Soc. ,2005,127: 2944—2959
[102]  Marcu K B,Bossone S A,Patel A J. Annu. Rev. Biochem. ,
[103]  Pelengaris S,Rudolph B,Littlewood T. Curr. Opin. Genet.
[104]  129—136
[105]  Pelengaris S,Khan M. Expert Opin. Ther. Targets,2003,7:
[106]  623—642
[107]  Cole M D,McMahon S B. Oncogene,1999,18: 2916—2924
[108]  Spencer C A,Groudine M. Adv. Cancer Res. ,1991,56: 1—
[109]  Facchini L M,Penn L Z. FASEB J. ,1998,12: 633—651
[110]  214: 456—459
[111]  37: 381—391
[112]  Boles T C,Hogan M E. Biochemistry,1987,26: 367—376
[113]  Yang D Z,Hurley L H. Nucleosides Nucleotides and Nucleic
[114]  Acids,2006,25: 951—968
[115]  Boles T C,Hogan M E. Biochemistry,1987,26: 367—376
[116]  Simonsson T, Pecinka P, Kubista M. Nucleic Acids Res. ,
[117]  1998,26: 1167—1172
[118]  Siddiqui-Jain A,Grand C L,Bearss D J,et al. Proc. Natl.
[119]  Acad. Sci. USA,2002,99: 11593—11598
[120]  Grand C L,Powell T J,Nagle R B,et al. Proc. Natl. Acad.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133