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化学进展  2002 

无机物的ADME/Tox研究

Keywords: 无机物,ADME/Tox,药物动力学,药物化学,金属离子

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Abstract:

无机物的吸收、分配、代谢和排除以及毒性(ADME/Tox)研究在药物和毒物研究中非常重要,近年来发展在细胞层次上应用高通量和计算机等技术系统探索药物先导化合物的ADME/Tox发展迅速。金属和其它无机化合物的ADME/Tox研究在国内外都还是一个新兴的、具有广阔发展前途的跨学科研究领域。本文综述了国内外对于铁和铜以及稀土等金属的化合物的ADME/Tox研究结果,提出了一些应该开展的工作和有待解决的问题。

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