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化学进展  2002 

酪氨酸激酶抑制剂的研究新进展

Keywords: 酪氨酸激酶,抑制剂,ATP,药效团模型

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Abstract:

蛋白质酪氨酸在一系列细胞活动的信号转导途径中起着重要的作用。在包括癌症和其他许多疾病的治疗研究中,酷氨酸激酶都是研究的目标和对象。本文综述了近年来酷氨酸激酶抑制剂的研究进展,包括抑制剂的结构和与激酶作用的药效团模型。

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