Purpose. To investigate the outcome and toxicity of stereotactic body radiotherapy (SBRT) in patients with oligo-recurrence cancer in the lung (ORCL). Methods and Materials. A retrospective review of 42 patients with ORCL who underwent SBRT in our two hospitals was conducted. We evaluated the outcome and adverse effects after SBRT for ORCL. Results. All patients finished their SBRT course without interruptions of toxicity reasons. The median follow-up period was 20 months (range, 1–90 months). The 2-year local control rate and overall survival were 87% (95% CI, 75–99%) and 65% (95% CI, 48–82%). As for prognostic factor, the OS of patients with a short disease-free interval (DFI) months, between the initial therapy and SBRT for ORCL, was significantly worse than the OS of long DFI months ( ). The most commonly observed late effect was radiation pneumonitis. One patient had grade 4 gastrointestinal toxicity (perforation of gastric tube). No other ≧？grade 3 acute and late adverse events occurred. There were no treatment-related deaths during this study. Conclusions. In patients with ORCL, radical treatment with SBRT is safe and provides a chance for long-term survival by offering favorable local control. 1. Introduction Lung is one of the common sites of metastasis after definitive therapy for a primary cancer. So far, recurrent or metastatic lung cancers have been considered to uniformly carry a poor prognosis because multiple metastases tend tobe difficult to treat intensively. Chemotherapy has been broadly applied as a standard managementat these conditions. On the other hand, the innovation of methods of early detection of recurrence, such as positron-emission tomography (PET), allows the detection of limited site recurrent, called oligo-recurrence. Oligo-recurrence, proposed by Niibeet al. in 2006 [1–4], was the condition of one or a few metastatic or recurrent lesions occurred with controlled primary lesion. For case with oligo-recurrence cancer in the lung (ORCL), the controversy exists regarding the optimal approach of these metastatic sites. Despite surgical approach is considered as an alternative for a single metastasis, there are many patients with ORCL who were not amenable for metastasectomy. For them, less invasive techniques such as SBRT have been used to treat ORCL. In cases considered to have a favorable prognosis, radical treatment with SBRT seems to be beneficial for prolonging the survival time. However, the role of radiotherapy and the prognostic factors for oligo-recurrencehave not yet been clearly elucidated [5]. In this study, we
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