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海洋科学  2012 

海洋褐藻叉开网翼藻中的单萜成分研究

, PP. 81-84

Keywords: 叉开网翼藻(Dictyopteris,divaricata,Okam.),化学成分,单萜,结构鉴定,活性筛选

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Abstract:

为了研究中国沿海海藻中的活性化学成分,利用正相硅胶柱色谱、SephadexLH-20柱色谱、反相HPLC及重结晶等手段,从采自青岛的褐藻叉开网翼藻(DictyopterisdivaricataOkam.)中首次分离得到了6个单萜类化合物,经红外波谱(IR),质谱(MS)及核磁共振波谱(1HNMR、13CNMR)等现代波谱技术鉴定为loliolide(1),isololiolide(2),3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one(3),dehydrovomifoliol(4),(3R)-4-(2R,4S)-2-hydroxy-2,6,6-trimethylcyclohexylidene-3-buten-2-oneiol(5),(3R)-4-(2R,4S)-4-acetoxy-2-hydroxy-2,6,6-trimethylcyclohexylidene-3-buten-2-one(6)。并通过MTT法对所得化合物进行细胞毒活性筛选,通过比色法进行乙酰胆碱酯酶抑制活性筛选。

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