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海洋科学  2011 

大菱鲆早期发育过程中免疫器官的发生

, PP. 62-67

Keywords: 大菱鲆(Scophthalmus,maximus),早期发育阶段,免疫器官,发生,组织学

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Abstract:

应用组织切片研究了大菱鲆(Scophthalmusmaximus)初孵仔鱼至60日龄幼鱼免疫器官的发育过程。结果表明,免疫器官原基出现的先后顺序是头肾、脾脏和胸腺。1日龄仔鱼可以观察到头肾原基,包含未分化的造血干细胞。5日龄时,脾脏原基出现,其淋巴化开始于27日龄且发育速度较慢。13日龄时,大菱鲆仔鱼胸腺原基出现,且发育速度较快,分为外区和内区。在大菱鲆早期发育过程中,胸腺和头肾之间出现细胞迁移现象。免疫器官淋巴化的顺序是胸腺、头肾和脾脏。在免疫器官发育后期,脾脏和头肾中均发现了黑色素-巨噬细胞中心(MMCs),脾脏中较丰富,但在胸腺中尚未发现。在大菱鲆仔鱼早期发育阶段,免疫器官尚未发育完善,非特异性防御机制起着重要的免疫作用。

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