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海洋科学  2011 

三种典型POPs 对紫贻贝不同组织DNA 损伤的比较研究

, PP. 32-37

Keywords: POPs,紫贻贝(Mytilus,edulis),彗星电泳,DNA,损伤

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Abstract:

采用彗星电泳技术,比较研究了Aroclor1254、BaP、DDT三种典型POPs对紫贻贝(Mytilusedulis)鳃、性腺、消化腺细胞的DNA损伤效应的差异,以期为进一步评价这三种典型POPs遗传毒理机制及其预警监测提供科学依据。结果表明,TailDNA%是评价DNA损伤的理想指标,另外,在急性毒性试验中,这三种POPs对紫贻贝鳃、性腺、消化腺细胞的DNA损伤作用均存在显著时间-剂量-效应关系,其中,BaP的DNA损伤作用最大,鳃和消化腺细胞对毒性作用较敏感。同时,对不同组织细胞的敏感性差异原因及其在环境监测中的应用进行了探讨。

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