Dyerberg J,Bang H O.Observations on populations in Greeland and Denmark,in nutritional evaluation of long-chain fatty acids[M].New York:Academic Press,1981.
[2]
Kang J X,Leaf A.The cardiac antiarrhythmic effects of polyunsaturated fatty acid[J].Lipids,1996,31:41-44.
Dss U.A radical approach to cancer[J].Med Sci Monit,2002,8:79-92.
[7]
Gill I,Valivety R.Polyunsaturated fatty acids,part 1:occurrence,biological activities and applications[J].Trends Biotechnol,1997,15:401-409.
[8]
James M J,Beringer C,Kless T.Dietary polyunsaturated fatty acid and inflammatory mediator production[J].Clin Nutr,2000,71:343-348.
[9]
Nettleton J A.Are n-3 fatty acids essential nutrients for fetal and infant development[J].J Am Diet Assoc,1993,93:58-64.
[10]
Ratledge C,Kanagachandran K,Anderson AJ,et al.Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source[J].Lipids,2001,36:1 241-1 246.
[11]
Swaaf M E,Pronk J T,Sijtsma L.Fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii on ethanol[J].Appl Microbiol Biotechnol,2003,61:40-43.
[12]
Swaaf M E,Grobben G J,Eggink G,et al.Characterisation of extracellular polysaccharides produced by Crypthecodinium cohnii on ethanol[J].Appl Microbiol Biotechnol,2001,57:395-400.
[13]
Zhu L Y,Zhang X C,Song X J,et al.Effect of temperature,salinity,pH,carbon and nitrogen sources on the growth and docosahexaenoic acid production of Schizochytrium limacinum[J].Process Biochem,2007,42(2):210-214.
Makoto S,Takio S,Kanji O.Low temperature-induced accumulation of eicosapentaenoic acid in Marchantia polymorpha cells[J].Phytochem,1999,52:367-372.
[17]
Renaud S M.Effect of temperature on the growth,total lipid content and fatty acid composition of recently isolated tropical microalgae Isochrysis sp.[J].J Appl Phycol,1995,7:595-602.
[18]
Suutari M,Laakso S.Microbial fatty acids and thermal adaptation[J].Crit Rev Microbiol,1994,20:285-328.
[19]
Sajbidor J.Effect of some environmental factors on the content and composition of microbial membrane lipids[J].Crit Rev Biotechnol,1997,17:87-103.
Steo A,Wang H L,Hessenltine C W.Cultured conditions affect eicosapentaenoic acid content of Chlorella minutissima[J].J Am Oil Chem Soc,1984,61(5):892-894.
Shu C H,Lung M Y.Effect of pH on the production and molecular weight distribution of exopolysaccharide by Antrodia camphorate in batch cultures[J].Process Biochem,2004,39:931-937.
Dss U N,Fams M D.Long-chain polyunsaturated fatty acids in the growth and development of the brain and memory[J].Nutrition,2003,19:62-65.
[29]
Crawford M A.The requirements of long-chain n-6 and n-3 fatty acids for the brain[J].Proc Am Oil Chem Soc,1987,24:270-295.
[30]
Giusto N M,Pasquare S J,Salvador P I,et al.Lipid metabolism in vertebrate retinal rod outer segments[J].Prog Lipid Res,2000,39:315-391.
[31]
Koueta N,Boucaud C E,Noel B.Effect of enriched natural diet on survival and growth of juvenile cuttlefish Sepia ctfficinalis[J].Aquaculture,2002,203:293-310.
[32]
Song X J,Zhang X C,Zhu L Y,et al.Evaluation of a DHA-rich Schizochytrium sp.as a diet enrichment for larval of marine aquaculture[J].Fisheries Science,2007,73(3):171-175.
[33]
Copeman L A,Parrish C C,Brown J A.Effects of docosahexaenoic,eicosapentaenoic and arachidonic acids on the early growth,survival,lipid composition and pigmentation of yellow-tail flounder (Limanda ferruginea):a live food enrichment experiment[J].Aquaculture,2002,210:285-304.
[34]
蒋汉明.优化海产微藻多不饱和脂肪酸生产条件的研究[D].汕头,汕头大学,2003.
[35]
Sijtsma L,Sweaf M E.Biotechnological production and applications of the omega-3 polyunsaturated fatty acid docosahexaenoic acid[J].Appl Microbiol Biotechnol,2004,64:146-153.
[36]
Barclay W R,Meager K M,Abril J R.Heterotrophic production of long chain omega-3 fatty acids utilizing algae and algae-like microorganisms[J].J Appl Phycol,1994,6:123-129.
[37]
Johnathan A N.Plumbing the depths of PUFA biosynthesis:a novel polyketide synthase-like pathway from marine organisms[J].Trends in Plant Science,2002,7:51-54.
[38]
Metz J G,Roessler P,Facciotti D,et al.Production of polyunsaturated fatty acids by polyketide synthetases in both prokaryotes and eukaryotes[J].Science,2001,293:290-295.
[39]
Achman R G,Jangaard P M,Hoyle R J,et al.Origin of marine fatty acids.Analysis of the fatty acids produced by the diatom Skeletonema costatum[J].J Fish Res Board Can,1964,21:747-756.
[40]
Servel M O,Claire C,Derrien A,et al.Fatty acid composition of some marine microalgae[J].Phytochemistry,1994,36:691-693.
[41]
Barclay W R,Meager K M,Abril J R.Heterotrophic production of long chain omega-3 fatty acids utilizing algae and algae-like microorganisms[J].J Appl Phycol,1994,6:123-129.
[42]
Yaguchi T,Tanaka S,Yokochi T,et al.Production of high yields of docosahexaenoic acids by Schizochytrium sp.strain SR21[J].J Am Oil Chem Soc,1997,74:1 431-1 434.
[43]
Barclay W R.Process for the heterotrophic production of products with high concentrations of omega-3 highly unsaturated fatty acids[P].America,World patent WO91/07498,1991.
[44]
Yokochi T,Honda D,Higashihara T,et al.Optimization of docosahexaenoic acid production by Schizochytrium limacinum SR21[J].Appl Microbiol Biotechnol,1998,49:72-76.
[45]
Fan K W,Chen F,Jones E B G,et al.Eicosapentaenoic and docosahexaenoic acids production by okara utilizing potential of traustochytrids[J].J Ind Microbiol Chem,2001,27:199-202.
[46]
Wu S T,Yu S T,Lin L P.Effect of culture conditions on docosahexaenoic acid production by Schizochytrium sp.S31[J].Process Biochem,2005,40:3 103-3 108.
[47]
Hammond B G,Mayhew D A,Naylor M W,et al.Safety assessment of DHA-Rich microalgae from Schizochytrium sp.:Ⅰ.Subchronic rat feeding study[J].Regulatory Toxicology and Pharmacology,2001,33:192-204.
[48]
Hammond B G,Mayhew D A,Holson,J F,et al.Safety assessment of DHA-Rich microalgae from Schizochytrium sp.:Ⅱ.Developmental toxicity evaluation in rats and rabbits[J].Regulatory Toxicology and Pharmacology,2001,33:205-217.
[49]
Hammond B G,Mayhew D A,Robinson K,et al.Safety assessment of DHA-Rich microalgae from Schizochytrium sp.:Ⅲ.Single-generation rat reproduction Study[J].Journal of Archaeological Science,2001,33:356-362.
[50]
Hammond B G,Mayhew D A,Kier L D,et al.Safety assessment of DHA-Rich microalgae from Schizochytrium sp.:Ⅳ.Mutagenicity studies[J].Regulatory Toxicology and Pharmacology,2002,35:255-265.
[51]
Abril R,Garrett J,Zeller S G,et al.Safety assessment of DHA-rich microalgae from Schizochytrium sp.Part Ⅴ:Target animal safety/toxicity study in growing swine[J].Regulatory Toxicology and Pharmacology,2003,37:73-82.
[52]
Swaaf M E,Rijk T C,Eggink G,et al.Optimisation of docosahexaenoic acid production in batch cultivations by Crypthecodinium cohnii[J].J Biotechnol,1999,70:185-192.
[53]
Swaaf M E.Docosahexaenoic acid production by the marine alga Crypthecodinium cohnii[D].Delft,Delft Technical University,PhD thesis,2003.
[54]
Swaaf M E,Sijtsma L,Pronk J T.High-cell-density fedbatch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii[J].Biotechnol Bioeng,2003,81:666-672.