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海洋科学  2007 

极大螺旋藻胞内多糖对体外肿瘤细胞抑制作用的实验研究

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Keywords: 极大螺旋藻(Spirulina,maxima),胞内多糖,细胞凋亡

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Abstract:

研究了极大螺旋藻(Spirulinamaxima)胞内多糖对SMMC7721等肿瘤细胞系的生长及凋亡的影响。在体外培养条件下,用半抑制浓度(80,5mg/L)的极大螺旋藻胞内多糖(IPSⅠ,IPSⅡ)处理肿瘤细胞,并用MTT,SRB,DNAladder,AnnexinⅤ等方法测定。结果表明,IPSⅠ(80mg/L)对SMMC7721,A549,HeLa,U251等肿瘤细胞系抑制率分别为64.97%、46.1%、43.3%、27.02%;IPSⅡ(5mg/L)能诱导SMMC7721细胞凋亡。

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