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海洋科学  2008 

苯并异噻唑啉酮衍生物的合成及其抑菌性能

, PP. 62-66

Keywords: 苯并异噻唑酮,合成,抑菌活性

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Abstract:

以1,2-苯并异噻唑-2(3H)-酮为原料合成了其新的衍生物2-(1,2-苯并异噻唑-2(3H)-酮)-乙酰肼和系列N'-(芳基亚甲基)-2-(1,2-苯并异噻唑-2(3H)-酮)-乙酰肼衍生物,目标化合物的结构经元素分析、IR、UV、1HNMR和质谱确证,并对其波谱性质进行了讨论。测试了苯并异噻唑啉酮化合物对5种水生菌大肠杆菌(Escherichiacoli)、金黄色葡萄球菌(Staphyloccusaurueus)、溶藻弧菌(Vibrioalginolyticus)、嗜水气单胞菌(Aeromonashydrophila)、枯草芽孢杆菌(Bacillussubtilis)的抑制活性。结果表明,此类化合物在100×10-6mol/L下抑菌率均达到90%以上,有良好的抑菌活性。

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