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科技导报  2015 

吉林人参低聚肽的免疫调节作用

DOI: 10.3981/j.issn.1000-7857.2015.18.010, PP. 62-67

Keywords: 人参低聚肽,免疫功能,细胞免疫,体液免疫,巨噬细胞吞噬能力,自然杀伤细胞活性

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Abstract:

为研究吉林人参低聚肽(GOP)对小鼠的免疫调节作用,选取280只SPF级雌性BALB/c小鼠,随机分为7组空白对照组、乳清蛋白组(150mg/kg)及5个GOP组(37.5、75、150、300、600mg/kg)。连续灌胃30d后,进行免疫7项实验测定,观察GOP对小鼠免疫器官相对重量、细胞免疫功能、体液免疫功能、单核-巨噬细胞功能和NK细胞活性的影响。结果表明GOP显著提高了ConA诱导的小鼠脾淋巴细胞增殖能力、迟发型变态反应能力、抗体生成细胞数、小鼠碳廓清指数、巨噬细胞吞噬率和吞噬指数、NK细胞活性(P<0.05),且效果优于乳清蛋白。由此可知,GOP可以通过增强细胞免疫功能、体液免疫功能、单核-巨噬细胞吞噬能力和NK细胞活性,起到增强免疫力的作用。

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