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科技导报  2014 

ACE基因多态性与异常体液型乳腺癌的易感性

DOI: 10.3981/j.issn.1000-7857.2014.36.010, PP. 65-68

Keywords: 异常体液型,乳腺癌,血管紧张素转换酶,多态性

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Abstract:

为探讨血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与新疆汉族人群乳腺癌的相关性,按维吾尔医将乳腺癌患者分为4种体液型,采用聚合酶链式反应(PCR)技术对新疆汉族139例乳腺癌患者和72例正常对照组ACE基因I/D多态性进行检测,比较各组间等位基因和基因型频率分布的差异。结果显示,异常黏质乳腺癌患者组II基因型频率(P=0.018)和I等位基因频率(P=0.004)都显著高于正常对照组;异常黏液质乳腺癌患者组I等位基因频率显著高于异常黑胆质乳腺癌患者组(P=0.012)。由此得出,ACE基因I等位基因和II基因型可能增加新疆汉族维吾尔医异常黏液质型乳腺癌的发病风险。

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