全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
科技导报  2014 

维药异常黑胆质成熟剂对乳腺增生模型大鼠乳腺组织病理形态及血清性激素水平的影响

DOI: 10.3981/j.issn.1000-7857.2014.26.011, PP. 79-84

Keywords: 异常黑胆质成熟剂,乳腺增生模型大鼠,病理形态学,性激素水平

Full-Text   Cite this paper   Add to My Lib

Abstract:

为探讨维药异常黑胆质成熟剂对乳腺增生模型大鼠的治疗作用及可能的作用机制,选用清洁级雌性Wistar大鼠60只,随机分为6组正常对照组、模型组、阳性对照组(三苯氧胺组)、异常黑胆质成熟剂高、中、低剂量组,采用大鼠右下肢肌肉注射雌、孕激素建立乳腺增生病模型,进行药物干预(三苯氧胺1.8mg/kg,胆质成熟剂高、中、低剂量分别为3.75、7.5、15g/kg)。运用光学显微镜观察维药异常黑胆质成熟剂对实验性乳腺增生症大鼠乳腺形态学的影响,放射免疫测定法检测其血清激素水平。结果表明,异常黑胆质成熟剂能减轻上皮细胞、间质纤维组织增生程度,改善模型大鼠乳腺组织病理形态学改变,调节血清激素水平,降低血清雌二醇(E2)、黄体生成素(LH)、升高孕酮(P)、睾酮(T)、催乳素(PRL)及卵泡刺激素(FSH)水平,与模型组比较具有统计学差异(P<0.01或P<0.05)。由此可见,异常黑胆质成熟剂对乳腺增生症大鼠的乳腺组织形态改变有一定的修复作用,同时能够降低大鼠血清雌激素水平,显著提高孕激素水平,且雌、孕激素比例失调状态也能够得到改善。

References

[1]  胡汉华, 盛磊, 哈木拉提·吾甫尔, 等. 维药异常黑胆质成熟剂的抗肿 瘤作用及其对细胞迁移的影响[J]. 科技导报, 2011, 29(3): 62-65. Hu Hanhua, Sheng Lei, Upur Halmurat, et al. Anti-cancer effects of Uighur medicine abnormal Savda Munzip and its influence on cell migration [J]. Science & Technology Review, 2011, 29(3): 62-65.
[2]  张拴成, 肖红玲, 王丽娜, 等. 消瘀通络散对乳腺增生模型大鼠血清激 素水平的影响[J]. 中国中医基础医学杂志, 2012, 18(1): 58-60. Zhang Shuancheng, Xiao Hongling, Wang Lina, et al. Effects of Xiaoyu Tongluo San on breast morphology and endocrine in rats with hyperplasia of mammary glands[J]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 2012, 18(1): 58-60.
[3]  马民, 李德辉, 张桂娟, 等. 乳癖霜外用对乳腺增生模型大鼠乳腺组织 病理形态学和AP-2et、C-erbB-2 表达的影响[J]. 中国老年学杂志, 2012, 32(4): 728-742. Ma Min, Li Dehui, Zhang Guijuan, et al. Effect of Rupi cream on histomorphology and AP-2et and C-erbB-2 expressions in rats with hyperplasia of mammary gland[J]. Chinese Journal of Gerontology, 2012, 32(4): 728-742.
[4]  中国医学百科全书编辑委员会. 中国医学百科全书:维吾尔医学[M]. 上海: 上海科学技术出版社, 2005: 26-30. Chinese Pharmacopoeia Commission. Traditional Uighur medicine of China medical encyclopaedia[M]. Shanghai: Shanghai Scientific and Technical Publishers, 2005: 26-30.
[5]  哈木拉提·吾甫尔. 维吾尔医学气质体液论及其现代研究[M]. 乌鲁木 齐: 新疆科学技术出版社, 2003: 44-52. Upur Halmurat. Theory of Mizaj and Hilit in Uighur medicine and modern study[M]. Urumqi: Xinjiang Scientific and Technical Publisher, 2003: 44-52.
[6]  阿衣努尔·买提斯迪克, 哈木拉提·吾甫尔, 玉山江, 等. 305例2型糖 尿病维医异常体液分型的量化诊断入选项专家咨询研究[J]. 科技导 报, 2012, 30(2): 39-45. Maitisidike Ayinuer, Upur Halmurat, Yu Shanjiang, et al. Screening of quantitative diagnosis indices of typing abnormal hilit syndrome in Uighur medicine using delphi method with 305 cases of type 2 diabetes[J]. Science & Technology Review, 2012, 30(2): 39-45.
[7]  哈木拉提·吾甫尔, 阿衣努尔·买提斯迪克, 吾尔古丽·阿卜都来海提, 等. 180例哮喘病维医异常体液分型的量化诊断入选项专家咨询研究[J]. 科技导报, 2011, 29(32): 36-42. Upur Halmurat, Maitisidike Ayinuer, Abudulaihait Wuerguli, et al. Screening of quantitative diagnosis indices of typing abnormal hilit syndrome in uighur medicine using delphi method, a survey of 180 cases of bronchial asthma [J]. Science & Technology Review, 2011, 29 (32): 36-42.
[8]  哈木拉提·吾甫尔. 能够使异常黑胆质型体液成熟和清除的药物及其 制备方法: 中国, 02130082.8[P]. 2003-04-16. Upur Halmurat. Preparation method of abnormal Savda Munziq and mishill on the effect of abnormal savda syndrome: China, 02130082.8[P]. 2003-04-16.
[9]  罗伦才, 季小平, 黄兰雅, 等. 均匀设计法用于乳腺增生动物模型复制 的研究[J]. 中国实验方剂学杂志, 2011, 17(7): 204-206. Luo Luncai, Ji Xiaoping, Huang Lanya, et al. Animal model replication of proliferative breast by homogeneous design[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2011, 17(7): 204-206.
[10]  高攀, 张秀军, 于玉领, 等. 蚌埠市农村已婚妇女乳腺疾病筛查及相 关因素调[J]. 中国妇幼保健, 2012, 27(3): 403-406. Gao Pan, Zhang Xiujun, Yu Yuling, et al. Screening of breast diseases and investigation on related factors among the married women in rural area of Bangbu city[J]. Maternal & Child Health Care of China, 2012, 27(3): 403-406.
[11]  许涛, 沈念春, 何造雄, 等. 乳腺增生症危险因素的病例对照研究[J]. 中国妇幼保健, 2009, 24(12): 1666-1668. Xu Tao, Shen Nianchun, He Zaoxiong, et al. A case-control study on risk factors of mammary hyperplasia[J]. Maternal & Child Health Care of China, 2009, 24(12): 1666-1668.
[12]  蔡鼎男, 林劲, 陈碧珠, 等. 体检人群中乳腺增生症患者的危险因素 调查[J]. 莆田学院学报, 2011, 18(2): 24-27. Cai Dingnan, Lin Jin, Chen Bizhu, et al. Research on risk factors of hyperplasia of mammary gland in physical examination opulation [J]. Journal of Putian University, 2011, 18(2): 24-27.
[13]  Allison K H, Eby P R, Kohr J, et al. Lehman atypical ductal hyperplasia on vacuum-assisted breast biopsy: Suspicion for ductal carcinoma in situ can stratify patients at high risk for upgrade[J]. Human Pathology, 2011, 42(1): 41-50.
[14]  哈木拉提·吾甫尔, 阿不都热依木·玉苏甫, 努尔买买提·艾买提. 维 吾尔医异常黑胆质新论[M]. 乌鲁木齐: 新疆人民出版社, 2009. Upur Hamulati, Yusup Abdiryim, Amat Nurmuhammat. New conception on the theory of Abnormal Sawda in Traditional Uighur Medicine[M]. Urumqi: Xinjiang People's Publishing House, 2009.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133