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科技导报  2015 

氘代二乙胺的制备

DOI: 10.3981/j.issn.1000-7857.2015.12.001, PP. 15-18

Keywords: 二乙胺-d10,氘代,制备

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Abstract:

二乙胺是一种重要的有机化工原料,常应用于医药中间体的合成;同时,二乙胺基也常成为药物分子中重要的活性结构片段。将N-烷基的氢(H)原子替换为氘(D)原子,可显著改善药物分子的药代动力学性质。本文发展了使用乙醇-d6为原料,通过三步反应制得二乙胺-d10的合成方法,总收率大于40%,氘代丰率大于98%,期望能够应用于新型氘代药物的研发过程中。

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