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科技导报  2015 

高效Domino反应合成5-(4-氟苯基)-11-(4-甲氧基苯基)-1H-吲哚[2,3-b]喹啉-1-酮化合物及其晶体结构表征

DOI: 10.3981/j.issn.1000-7857.2015.03.002, PP. 19-23

Keywords: Domino反应,吲哚[2,3-b]喹啉,晶体结构

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Abstract:

使用简便、易得的3-(4-甲氧基苯甲酰亚甲基)羟吲哚和3-(4-氟苯基氨基)-2-环己烯-1-酮为原料,在乙醇钠和乙醇的共同作用下,一步合成得到5-(4-氟苯基)-11-(4-甲氧基苯基)-1H-吲哚[2,3-b]喹啉-1-酮化合物。通过单晶X衍射法确定其结构,晶体属单斜晶系,空间群Cc,分子量Mr=537.57(包含1分子溶剂DMF),晶胞参数a=1.44352(3)nm,b=2.6027(3)nm,c=0.93423(8)nm,V=2.6917(4)nm3,Z=4,晶胞密度Dc=1.327Mg/m3,吸收系数μ=0.093mm-1,单胞中电子的数目F(000)=1128。晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终的偏离因子为R=0.0631,Rω=0.1535。在晶体结构中新形成的含氮六元杂环近似于平面结构。

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