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科技导报  2015 

SH2D7基因及其编码蛋白的生物信息学分析

DOI: 10.3981/j.issn.1000-7857.2015.02.003, PP. 35-38

Keywords: 肿瘤,SH2D7,生物信息学分析

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Abstract:

为了对SH2D7基因序列及其编码蛋白进行生物信息学分析,应用NCBI数据库和ExPASy等程序,对SH2D7基因核苷酸序列进行了分析,并预测了其编码蛋白的理化性质及二级结构等。结果表明,SH2D7基因定位于人类染色体15q25.1,包含了6个外显子和5个内含子。SH2D7基因编码蛋白的功能主要涉及基因表达调控、信号传导等;分子量约为49.8kD,等电点为5.99,是一种亲水蛋白,主要位于细胞核中,有35个磷酸化位点及22个抗原位点。

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