全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
科技导报  2014 

异常黑胆质性哮喘血栓前状态的变化特点

DOI: 10.3981/j.issn.1000-7857.2014.17.010, PP. 64-70

Keywords: 异常黑胆质型,支气管哮喘,血栓前状态

Full-Text   Cite this paper   Add to My Lib

Abstract:

为探讨新疆维吾尔族异常黑胆质型哮喘患者血栓前状态的变化特点,对76例哮喘患者按维医体液论进行辨证分型(其中异常黑胆质型哮喘组30例,非异常黑胆质型哮喘组46例),并与健康对照组89名进行对照,检测血小板膜表面糖蛋白CD41和CD62P、内皮素(ET-1)、组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原激活物抑制剂-1(PAI-1)和凝血4项指标,即血浆纤维蛋白原(FIB)水平、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)。研究发现,与正常对照组相比,异常黑胆质性哮喘组和非异常黑胆质性哮喘组CD62P、ET-1、PAI-1水平均升高,差异有统计学意义(P<0.05),且异常黑胆质性哮喘组CD62P、ET-1、PAI-1水平高于非异常黑胆质性哮喘组,差异有统计学意义(P<0.05)。与正常对照组相比,异常黑胆质性哮喘组和非异常黑胆质性哮喘组t-PA含量均降低,差异有统计学意义(P<0.05),且以异常黑胆质性哮喘组下降较明显,差异有统计学意义(P<0.05)。与正常对照组相比,异常黑胆质性哮喘组和非异常黑胆质性哮喘组FIB含量明显升高,差异有统计学意义(P<0.01),且异常黑胆质性哮喘组FIB含量高于非异常黑胆质性哮喘组,差异有统计学意义(P<0.05)。APTT、PT时间较正常对照组偏短,差异有统计学意义(P<0.05),APTT、PT时间在异常黑胆质性哮喘组最短,其次为非异常黑胆质性哮喘组。研究表明,异常黑胆质性哮喘患者的血管内皮细胞、血小板、凝血和纤溶功能都发生紊乱,提示异常黑蛋质性哮喘处于血栓前状态,且这种状态较非异常黑胆质性哮喘更为突出。

References

[1]  中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J]. 中华结核和呼吸杂志, 2003, 26(3): 132-136. Bronchial Asthmatic Group of Respiratory Medicine Branch of Chinese Association. The Chinese medical association respiratory epidemiology (Bronchial asthmatic diagnosis and treatment guidelines) [J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2003, 26(3): 132-136.
[2]  巴克·阿里木阿吉. 维吾尔医诊断学[M]. 乌鲁木齐: 新疆人民卫生出版社, 2012: 111-120. Alemajim Bak. Uighur medical diagnostics[M]. Urumqi: Xinjiang People's Medical Publishing House, 2012: 111-120.
[3]  哈木拉提·吾甫尔. 维吾尔医气质、体液论及其现代研究[M]. 乌鲁木齐: 新疆科学技术出版社, 2003: 40-47. Upur Halmurat. Theory of mizaj and hilit in uighur medicine and mordern study[M]. Urumqi: Xinjiang Science and Technology Publishing House, 2003: 40-47.
[4]  Dunn E J, Grant P J. Type 2 diabes: Anatherothrombotic syndrome[J]. Current Molecular Medicine, 2005, 5(3): 323-332.
[5]  Lip G Y, Edmunds E, Beevers D G. Should patients with hyper-tension receive antithrombotic therapy?[J]. Journal of Internal Medicine, 2001, 249(3): 205-214.
[6]  严宗毅, 魏茂元, 于天文. 血液流变学[M]. 哈尔滨: 黑龙江科学技术出版社, 1993: 209-215. Yan Zongyi, Wei Maoyuan, Yu Tianwen. Hemorheology[M]. Harbin: Heilongjiang Science and Technology Publishing House, 1993: 209-215.
[7]  Korbut R, Gryglewski R J. The effect of prostacyclin and nitric oxide on deformability of red blood cells in septic shock in rats[J]. Physiology and Pharmacology, 1996, 47(4): 591-599.
[8]  Baskurt O K, Gdmont D, Meiselman H J. Red blood cell deformability in sepsis[J]. American Journal of Respiratory and Critical Care Medicine, 1998, 157: 421-427.
[9]  武焕玲, 林隆玖. 血栓前状态研究进展[J]. 中国实验诊断学, 2003, 7 (4): 277-280. Wu Huanling, Lin Longjiu. The reviewed of prethromboticseate[J]. Chinese Journal of Laboratory Diagnosis, 2003, 7(4): 277-280.
[10]  李家增. 血管血栓性疾病的发病机制和防治[J]. 基础医学与临床,2006, 26(6): 561-565. Li Jiazeng. Pathogenic mechanism and treatment of vascular thromboenbolismdisease[J]. Basic Medical Sciences and Clinics, 2006, 26 (6): 561-565.
[11]  Ferguson J J, Waly H M, Wilson J M. Fundamentals of coagulation and glycoprotein IIb/IIIa receptor inhibition[J]. European Heart Journal, 1998, 19(S1): D3.
[12]  徐宜, 孙文学. 老年糖尿病肾病血小板活化分子检测的意义[J]. 黑龙江医学, 2004, 28(1): 26-28. Xu Yi, Sun Wenxue. Significance of detection of platelet activation markers in elderly diabetic nephropathy[J]. Heilongjiang Medical Journal, 2004, 28(1): 26-28.
[13]  Zizzi H C, Zibari G B, Granger D N, et al. Quantification of P-selectin expression after renal ischemia and reperfusion[J]. Journal of Pediatric Surgery, 1997, 32(7): 1010-1013.
[14]  Miamino T, Kitakase M, Sanada S, et al. Increased expression of P-selection on platelets is a risk factor for silent cerebalinfaction in patients with atrial fibrillation[J]. Circulation, 1998, 98(3): 1721-1727.
[15]  Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells[J]. Nature, 1988, 332(6163): 411-415.
[16]  陶连方. 老年高血压病糖尿病患者血浆内皮素测定及其意义[J]. 中国微循环, 2003, 7(4): 245. Tao Lianfang. Significance of detection of plasma endothelium in elderly diabetic nephropathy and hypertension[J]. Journal of Chinese Microcirculation, 2003, 7(4): 245.
[17]  Nguyen-Ho P, Lakkis N M. Platelet glycoprotein IIb/IIIa a receptor antagonists and coronary disease[J]. Current Atherosclerosis Reports, 2001, 3(2): 139-148.
[18]  王振义, 李家增, 阮长耿, 等. 纤维蛋白溶解系统[C]//上海第二医科大学编辑委员会. 血栓与止血基础理论与临床. 2版. 上海: 上海科学技术出版社, 1996. Wang Zhenyi, Li Jiazeng, Ruan Changgeng, et al. Fibrinolytic system[C]//Editorial Committee of Shanghai Second Medical University. The Basic Theory and Clinical of Thrombosis and Haemostasis. 2nd ed. Shanghai: Shanghai Science and Technology Publishing House, 1996.
[19]  丛玉隆, 王淑娟, 朱士俊, 等. 纤溶系统的组成及特点[C]//今日临床检验学编辑委员会编. 今日临床检验学. 北京: 中国科学技术出版社, 1997. Cong Yulong, Wang Shujuan, Zhu Shijun, et al. The composition and the characteristics of fibrinolytic system[C]//Today Clinical Inspection Editorial Board. Today Clinical Test. Beijing: China Science and Technology Publishing House, 1997.
[20]  Bernd R B, Gunter C, Florian G, et al. Plasminogen activator inhibitor physiological and pathophysiological roles[J]. Newsin Physiological Sciences, 2002, 17: 56-61.
[21]  葛郁芝, 刘冬生. 高血压病患者血栓前状态P-选择素等标志物变化及其临床意义[J]. 中国心血管病研究杂志, 2005, 3(12): 896-899. Ge Yuzhi, Liu Dongsheng. Levels of P selection and its clinic significance in hypertensive patients with prothromboticstatus[J]. Chinese Journal of Cardiovascular Review, 2005, 3(12): 896-899.
[22]  Qizilbash N, Duffy S, Prentice C R M, et al. Willebrand factor and risk of ischemic stroke[J]. Neurology, 2001, 53(6): 1552-1556.
[23]  Yamell J W G, Baker I A. Sweetnam P M, et al. Fibrinogen, viscosity and white blood cell count are major risk factor for ischemic heart disease[J]. Circulation, 1991, 83: 836.
[24]  居来提·托乎提, 阿不都克热木江·吐尔逊托乎提. 维吾尔医学对哮喘病因的认识[J]. 中国民族医学杂志, 2004, 10(4): 3-4. Tuohuti Julaiti, Tuerxuntuohuti Abudukeremujian. Recognize on the Uygur traditional medicine for asthma cause[J]. Journal of Medicine & Pharmacy of Chinese Minorities, 2004, 10(4): 3-4.
[25]  Bauer K A, Rosenberg R D. The pathophysiology of the perthrombotic state in humans: Insights gained from stadies using markers of hemostatic system activation[J]. Blood, 1987, 70(2): 343-350.
[26]  常玉荣, 杨德全, 唐福美, 等. 血栓栓塞性疾病血栓前状态的实验室诊断[J]. 中国综合临床, 2001, 17(2): 83. Chang Yurong, Yang Dequan, Tang Fumei. Thromboembolic disease before thrombus state laboratory diagnosis[J]. Clinical Medicine of China, 2001, 17(2): 83.
[27]  Beather E, LichtmanM A, Coller B S, et al. Hematollgy[M]. 6th ed. New York: McGraw Hill, 2001: 1735-1763.
[28]  宗俊学, 芦璐, 徐洪玉. 血栓前状态与高血压病的关系[J]. 血栓与止血学, 2005, 11(1): 21-23. Zong Junxue, Lu Lu, Xu Hongyu. The relationship between prethromboticseate and hypertension[J]. Chinese Journal of Thrombosis and Hemostasis, 2005, 11(1): 21-23.
[29]  Falanga A, Tickles F R. Pathophysiology of the thrombophilic state in the cancer patient[J]. Seminars in Thromband Hemostasis, 2002, 25(2): 173-182.
[30]  Sarkar R R, Banerjee S. Cancer self remission and tumor stability a stochastic approach[J]. Mathematical Biosciences and Engineering, 2005,196(1): 65-81.
[31]  CalveteJ J. Clues for understanding the structure and function of a prototypic human integrin: The platelet glycoproteinIIb/III acomplex[J]. Thrombosis andHaemostasis, 1994, 7(1): 11-16.
[32]  Egidy G, Juillerat J L, Jeannin J F, et al. Modulation of human colon tumor-stromalinter actions by the endothelin system[J]. American Journalof Pathology, 2000, 157(6): 1863-1874.
[33]  Calvete J J. Clues for understanding the structure and function of a prototypic human integrin: The platelet glycoproteinIIb/III acomplex[J]. Thrombosis and Haemostasis, 1994, 7(1): 11-16.
[34]  Erlandsen S L, Bittermann A G, White J, et al. High-resolutioncryofesemof individual cell adhesion molecules (CAMs) in theglycocalyx of human platelets: Detection of P-selectin(CD62P), GPI-IX complex (CD42a/CD42b, b?), and integrin GPIIb/IIIa(CD41/CD61) byimmunogold labeling and stereo imaging[J]. Journal of Histochemistry and Cytochemistry, 2001, 49(7): 809-819.
[35]  Suzuki S, Hayashi Y, Wang Y, et al. Urokinase type pkasminogen activator receptor expression in colorectal neoplasms[J]. Gut, 1998, 43(6): 798-805.
[36]  哈木拉提·吾甫尔. 维吾尔医学气质、体液论及其现代研究[M]. 乌鲁木齐: 新疆科学技术出版社, 2003, 7: 75-77. Upur Halmurat. Theory of mizaj and hilit in Uighur medicine and mordern study[M]. Urumqi: Xinjiang Science and Technology Publishing House, 2003, 7: 75-77.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133