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科技导报  2014 

异常黑胆质型肝癌病证模型肝脏形态学研究

DOI: 10.3981/j.issn.1000-7857.2014.14.012, PP. 74-78

Keywords: 维吾尔医,异常黑胆质,二乙基亚硝胺,肝癌

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Abstract:

为探讨异常黑胆质体液对异常黑胆质型肝癌病证模型的影响,在异常黑胆质载体大鼠模型基础上用二乙基亚硝胺(DEN)诱导建立维吾尔医异常黑胆质型肝癌病证模型大鼠,并对大鼠第11、15、20周时肝脏的外观、病理变化等进行动态观察。20周后,异常黑胆质病证模型组和模型对照组均发生癌变,前者成癌率(100%)明显高于后者(72%)(P<0.01)。总之,在异常黑胆质载体大鼠模型的基础上,用DEN诱导的异常黑胆质型肝癌病证模型肝癌的发生过程中,异常黑胆质体液具有促进和加快肝脏病变的作用。本研究成功建立了异常黑胆质并DEN诱导的肝癌病证大鼠模型。

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