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添加呋喃苯胺酸对低温诱导肉鸡肺动脉高压综合征的发病率及肺血管重构的影响

DOI: 10.7685/j.issn.1000-2030.2006.04.020, PP. 97-101

Keywords: 肉鸡,肺动脉高压综合征,呋喃苯胺酸,血管重构

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Abstract:

240羽肉鸡于14日龄时随机分为常温对照组(A)、低温对照组(B)和低温呋喃苯胺酸添加组(C)。分别于14、23、30、37、44日龄从各组随机抽取10羽肉鸡采血和扑杀,测定肺血管管壁面积与管总面积之比(WA/TA)、平均中膜厚度(mMTPA)等各项指标。观察在低温环境下呋喃苯胺酸对肉鸡肺动脉高压综合征(PHS)的防治效果及其对肉鸡肺血管重构的影响。试验结果显示,与A组相比,B组PHS发病率升高,右心全心比(RV/TV)、红细胞压积(PCV)和反映血管重构指标的WA/TA和mMTPA值显著升高(P<0.05);而C组与B组相比,PHS发病率降低,RV/TV、WA/TA和mMTPA值均降低,并在44日龄差异显著(P<0.05),PCV值升高但无显著差异,体质量显著降低。提示降低肺动脉压,抑制以肺动脉壁肥厚为特征的血管重构可能是呋喃苯胺酸有效降低低温所致PHS发病率的原因之一。

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