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水牛静脉注射葡萄糖后血糖水平的调节机制研究

DOI: 10.7685/j.issn.1000-2030.2006.02.016, PP. 75-79

Keywords: 水牛,糖代谢,血糖,血浆胰岛素/血糖值,胰岛素/胰高血糖素值

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Abstract:

12头健康禁食公水牛分为3组。组Ⅰ(n=6)与组Ⅱ(n=3)分别经颈静脉快速注射50%葡萄糖和0.9%生理盐水各2mL.kg-1;组Ⅲ(n=3)为对照,不作处理。分别于注射前60、10min及注射后1、5、10、30、60、120、180、240、300、360和420min采血,立即测定血浆葡萄糖及胰岛素和胰高血糖素,分析各指标间的相关性及血浆胰岛素/血糖值(IGR1)和胰岛素/胰高血糖素值(IGR2)。结果显示注射前,各组水牛血浆葡萄糖、胰岛素和胰高血糖素的浓度接近。组Ⅱ和组Ⅲ水牛的上述指标在所有采样时间点上组内和组间均未表现出显著性差异(P>0.05),IGR1和IGR2也没有明显变化。组Ⅰ水牛静注葡萄糖1min后血糖浓度迅速升至峰值,而血浆胰岛素30min后才升高(约20倍)至峰值,然后两者均缓慢下降,直到420min仍明显高于注射前的水平(P0.05)。提示水牛胰岛素代谢迟缓,对静注的葡萄糖清除缓慢,表现出持续性高血糖症和高胰岛素血症;水牛对于静注葡萄糖的反应不同于奶牛、犬、马等其他动物。

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