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恩诺沙星在异育银鲫体内的组织分布及消除规律

DOI: 10.7685/j.issn.1000-2030.2012.04.020, PP. 110-114

Keywords: 恩诺沙星,异育银鲫,组织分布,消除规律

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Abstract:

在24~26℃水温条件下,以10mg?kg-1剂量,用高效液相色谱法检测组织中药物浓度,研究静脉注射和口服给药后恩诺沙星在健康异育银鲫组织内的代谢分布规律。结果表明静脉注射后,药物在组织中代谢动力学特征符合二室模型;口服给药后,药物吸收良好,生物利用度(F)为86%,组织药物浓度-时间曲线呈现双峰,推测是由于药物在异育银鲫体内的肠肝循环作用所致。静脉注射和口服两种给药方式下,恩诺沙星在异育银鲫体内均具有良好的组织分布,肾脏、肌肉、肝胰脏、鳃和血液5种组织中的药物浓度时间曲线下总面积(AUC)分别为624.2、965.9、721.8、298.0、239.6μg?h?mL-1和465.3、343.1、542.9、411.4、205.9μg?h?mL-1,最大药物浓度(Cmax)分别为33.48、16.91、26.44、18.71μg?g-1和15.30μg?mL-1,9.20、5.39、7.78、6.88μg?g-1和4.50μg?mL-1;药物在各组织中消除时间较长,消除半衰期(T1/2β)分别为169.0、141.4、113.4、36.7、63.5h和27.3、49.2、77.0、38.5、62.7h。结论恩诺沙星以10mg?kg-1剂量单次口服给药,对细菌引起的异育银鲫病可以起到较好的治疗作用,但需注意药物残留问题。

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