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胆酸负荷对妊娠母羊血浆某些激素的影响

DOI: 10.7685/j.issn.1000-2030.2000.01.017, PP. 67-70

Keywords: 绵羊,妊娠,胆酸灌注,雌二醇,孕酮

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Abstract:

6只考力代妊娠母羊随机分成试验组和对照组。安装颈静脉血管瘘后,试验组羊灌注胆酸溶液(剂量2mg/kg,用生理盐水配制2g/L,灌注时间5min),对照组羊灌注等量生理盐水。在灌注前和灌注后2,4,8,12,24,72,120,168,216h分别采取血样,用放射免疫法测定血浆中雌二醇(E2)、孕酮(P)、皮质醇(Cort)等激素水平。结果表明母羊灌注胆酸后血浆E2水平显著下降,对照组(17626±1656)pg/mL,试验组(12366±1031)pg/mL(P<005);P和Cort水平显著上升,对照组分别为(0284±0029)mg/mL和(5816±0222)mg/mL,试验组分别为(0701±0071)ng/mL和(8571±0845)ng/mL(P<001);E2与P的比例也发生变化。说明胆酸对胎盘功能有较大影响,这可能是胎儿预后不良的主要原因。

References

[1]  Reyes H.Review:intrahepatic cholestasis,a puzzling disorder of pregnancy[J].Journal of Gastroenterology and Hepatology.1997,12(3):211-216
[2]  Thomsen O O,Larsen J A.Interaction of insulin,glucagon and DBcAMP on bile acid-independent bile production in the rat[J].Scandinavian Journal of Gastroenterology.1982,17(5):687-693
[3]  Alonso J R,Milenko B I,Alejando M.ICP:a retropective case-control study of perinatal outcome[J].American Journal of Obstetrics and Gynecology.1994,170(3):890-895
[4]  卢青,时浩,毛鑫智.妊娠大鼠胆酸负荷对母体和胎儿血清葡萄糖和激素水平及胎儿生长发育的影响[J].中国应用生理学杂志.1999,15(1):110-111
[5]  王淑贞.妇产科理论与实践[M].上海:上海科学技术出版社.1981:42
[6]  吴其夏.体液因素和血病理生理学[M].北京:北京医科大学中国协和医科大学联合出版社.1991:96
[7]  Johnston W G,Baskett T F.Obstetric cholestasis:a 14 year review[J].American Journal of Obstetrics and Gynecology.1979,133(3):299-301
[8]  井爱英.妊娠肝内胆汁淤积症的药物治疗进展[J].医学综述.1999,5(2):115-117
[9]  王建辰.家畜生殖内分泌学[M].北京:中国农业出版社.1993:195-215
[10]  董伟.家畜的生殖激素[M].北京:中国农业出版社.1985:256-303
[11]  Vlahcevic Z R,Heuman D M,Hylemon P B.Regulation of bile acid synthesis[J].Hepatology.1991,13(2):591-599
[12]  Lillienau J,Crombie D L,Munoz J.Negative feedback regulation of the ileal bile acid transport system in rodents[J].Gastroenterology.1993,104(1):38-46
[13]  Lunzer M,Barnes P,Byth K.Serum bile acid concentrations during pregnanty and their relationship to obstetric cholestasis[J].Gastroenterology.1986,91(4):825-829
[14]  Pasanen M,Helin Martikainen H L,Pelkonen O.Intrahepatic cholestasis of pregnancy impairs the activities of human placental xenobiotic and steriod metabolizing enzymes in vitro[J].Placenta.1997,18(1):37-41
[15]  Fisk N M,Story G N.Fetal outcome in obstetric cholestasis[J].British Journal of Obstetrics and Gynaecology.1988,95(11):1137-1143
[16]  谢渭芬.妊娠特有的肝病[J].国外医学(消化系疾病分册).1992,12(2):74-76
[17]  田开?.产科内分泌[M].北京:人民卫生出版社.1981:133
[18]  田开?.产科内分泌[M].北京:人民卫生出版社.1981:323-353

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