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北方园艺  2012 

RNA干扰机制及应用研究进展

, PP. 191-193

Keywords: RNA干扰,dsRNA,转录后基因沉默

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Abstract:

RNA干扰是外源和内源的双链RNA(double-strandRNA,dsRNA)特异性诱导生物体内同源靶基因mRNA的降解,从而导致转录后基因沉默的现象。目前对于RNA干扰机制已有深入研究,同时RNA干扰在抑制有害基因表达、功能基因组学及基因治疗等方面的应用研究也取得了较大进展。现主要综述了RNA干扰的作用机制、作用特点和技术应用等方面的研究进展。

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