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保肝Ⅰ号抗CCl4联合高脂饲料所致大鼠肝纤维化研究

Keywords: 保肝Ⅰ号,肝纤维化,四氯化碳,高脂饮食

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Abstract:

研究保肝Ⅰ号(BGYH)对四氯化碳(CCl4)和高脂饮食联合诱导的大鼠肝纤维化的治疗作用.40%CCl4-大豆油灌胃联合高脂饲料建立肝纤维化模型.建模结束后模型组重新分组后用BGYH高、中、低剂量灌胃连续治疗17d,进行肝脏病理和血清学检测.检测结果表明BGYH能够减轻肝纤维化大鼠的脂肪变性和组织增生,降低肝纤维化模型大鼠血清中谷草转氨酶(AST)、谷丙转氨酶(ALT)含量,增加血清白蛋白(ALB),降低血清中透明质酸(HA),肝脏中羟脯氨酸(Hyp)和Ⅰ型胶原蛋白(ColⅠ)的.BGYH能够降低肝纤维化大鼠肝脏中的转氨酶水平,保护肝功能,减轻肝脏脂肪变性和纤维组织增生,具有显著抗肝纤维化的作用.

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