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酸浆对炎症及花生四烯酸代谢途径的影响

DOI: 10.15918/j.tbit1001-0645.2015.07.020

Keywords: 酸浆 抗炎 镇痛 花生四烯酸代谢途径

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Abstract:

探讨酸浆的抗炎镇痛作用及机制. 抗炎实验采用角叉菜胶致大鼠足肿胀和大鼠棉球肉芽肿模型;镇痛实验采用小鼠扭体法. 各模型均随机分为4组:模型组、阳性药吲哚美辛组、酸浆宿萼提取物高剂量组、低剂量组. 测定大鼠足肿胀度,胸腺、脾脏指数,肉芽肿干重,观察小鼠扭体情况,检测足肿胀模型血清中磷脂酶A2(phospholipaseA2, PLA2)、环氧合酶-2(cyclooxygenase 2, COX-2)、前列腺素E2(prostaglandin E2, PGE2)、5-脂氧合酶(5-lipoxygenase, 5-LOX)、白三烯B4(leukotriene B4, LTB4)水平. 实验表明:酸浆宿萼提取物对急、慢性炎症均有显著抑制作用且对机体免疫器官具有一定的保护作用,对急性炎症血清中PLA2、COX-2、PGE2、5-LOX、LTB4均具有抑制作用. 酸浆宿萼提取物可能通过抑制COX-2、5-LOX活性从而双重抑制花生四烯酸(arachidonic acid, AA)代谢途径发挥抗炎作用

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