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新的糖/茂钛化合物的合成及其生物活性研究

Keywords: 二氯化二茂钛,糖/茂钛化合物,子宫颈癌,肝癌,肝靶向

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Abstract:

用4种含糖基团取代二氯化二茂钛中的氯,合成了4种新的糖/茂钛化合物:乳糖酸根一氯化二茂钛C12H21O12·C10H10TiCl,质酸根一氯化二茂钛C14H20NO11·C10H10TiCl·8H2O,乳糖酸根一质酸根二茂钛C12H21O12·C14H20NO11·C10H10Ti·26H2O和乳糖酸酰胺乙酸根一氯化二茂钛C14H24NO13C10H10TiCl.化合物都经过红外光谱、核磁共振、元素分析表征,并用MTT法研究了化合物对人体子宫颈癌细胞增殖体外实验.研究表明新合成的化合物都溶于水,对癌细胞有很好的抑制作用,糖结构的引入有明显的肝靶向效应.

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