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龙血竭总酚活血化瘀活性成分的虚拟筛选及初步活性研究

DOI: 10.15918/j.tbit1001-0645.2015.02.021

Keywords: 龙血竭 活血化瘀 虚拟筛选 活性

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Abstract:

应用Discovery Studio虚拟筛选软件,以凝血酶为受体,对龙血竭总酚活血化瘀有效成分进行了虚拟筛选. 虚拟筛选确定的受试成分对体外凝血酶活性的影响数据表明,计算机辅助虚拟筛选结果与体外药理实验结果基本符合. 受试成分龙血素A、龙血素B、龙血素C、7-羟基-4'-甲氧基黄烷、4',7-二羟基高异黄烷能抑制体外凝血酶活性,具有活血化瘀的药理作用

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